Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1003):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-148842

C14-4		99.01%
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity.

HY-130462

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC		99.96%
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.

HY-144004

DSPE-PEG2000-Mal ammonium		99.90%
DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents.

HY-138171

Lipid 5		99.78%
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.

HY-141613

1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium		98.0%
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium (DOPS-NA) is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used together with DOPC and DOPE in lipid mixtures for the synthesis of liposomes. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can self-assemble into single-layer or double-layer membrane structures, similar to cell membranes, and possesses high membrane fluidity and flexibility. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine is widely applied in membrane biology, cell membrane research, lipid preparation, and drug delivery systems.

HY-111915

1,2-Dioleoyl-sn-glycero-3-phosphate sodium salt		99.44%
1,2-Dioleoyl-sn-glycero-3-phosphate sodium salt (18:1 PA sodium salt) is an anionic lipid that can be used to prepare liposomes, micelles and artificial membranes.

HY-130751

DODAP		99.65%
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation.

HY-46760

LP01		99.81%
LP01 (Example 13) is a cationic lipid used in the delivery of biologically active agents to cells and tissues.

HY-148559

4A3-SC8		99.93%
4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model.

HY-W591381

DSG-PEG2000		99.97%
DSG-PEG2000 (DSG-PEG2000 2000) is a type of polyethylene glycol grease. DSG-PEG2000 can be used to prepare liposomes[2].

HY-W440835

DSPE-PEG2000-DBCO		99.90%
DSPE-PEG2000-DBCO is a phospholipid-PEG polymer that can be used to form micelles as lipid nanoparticles for drug delivery. DSPE-PEG2000-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-W127378

DOTAP methylsulfate		99.94%
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design.

HY-125854

Phosphatidylcholines, egg		99.79%
Phosphatidylcholines, egg are a type of phosphatidylcholine that can be isolated and extracted from eggs, primarily present in egg yolks. As a major phospholipid component of cell membranes, Phosphatidylcholines, egg play a key role in providing nutrition and protection to the body. Phosphatidylcholines, egg can inhibit oxidative stress and neurotoxicity, exerting neuroprotective effects. Additionally, Phosphatidylcholines, egg can suppress the lymphatic absorption of cholesterol in the intestine and are also used in research on intestinal lipid absorption.

HY-109541

Colfosceril miristate		99.96%
Colfosceril miristate (DMPC) is a synthetic phospholipid. Colfosceril miristate has antiproliferative effects on various tumors. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.

HY-166648

DSPE-PEG2000-Maleimide sodium (purity>99%)		99.97%
DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery.

HY-125924

DSPE-PEG-Amine, MW 2000 ammonium		99.96%
DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.

HY-154831

C22-Ceramide (d18:1/22:0)		99.89%
C22-Ceramide (d18:1/22:0) (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide (d18:1/22:0) reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes.

HY-112758

DLin-KC2-DMA		99.88%
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies.

HY-141571

DOPG sodium		99.44%
DOPG sodium is a naturally occurring anionic phospholipid, containing oleic acid (18:1) inserted at the sn-1 and sn-2 positions. DOPG can form a lipid bilayer in an aqueous solution and is used in the generation of micelles, liposomes, and other artificial membranes. DOPG also exhibits anti-inflammatory properties.

HY-W250118

Cephalin form bovine brain		98.0%
Cephalin form bovine brain is an orally active phospholipid widely present in organisms.Cephalin form bovine brain participates in the formation of autophagosome membrane as a lipid anchor of autophagy-related protein Atg8/LC3. Cephalin form bovine brain enhances Autophagic flux, promotes cell differentiation, regulates lipid droplet fusion, delays aging, and also affects lipid metabolism and membrane integrity.

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