144189-73-1
Chemical Structure
DOTAP methylsulfate
Synonym(s): 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
- CAS No.: 144189-73-1
- Formula:C43H83NO8S
- Molecular Weight:774.19
IUPAC Name: N,N,N-trimethyl-2,3-bis(oleoyloxy)propan-1-aminium methyl sulfate
InChIKey: RSMRWWHFJMENJH-LQDDAWAPSA-M
SMILES: S(OC)(=O)(=O)[O-].C(OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C
Biological Activity:
DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) methylsulfate is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfate promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfate can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DOTAP methylsulfate | 99.94% | DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) methylsulfate is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfate promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfate can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design |
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Similarity Score 0.96
HY-W127426DOTAP mesylate -
Similarity Score 0.93
HY-112754AGLDOTAP chloride (GMP Like) -
Similarity Score 0.93
HY-1651211,2-Dioleoyl-3(R)-trimethylammoniumpropane chloride -
Similarity Score 0.93
HY-1651221,2-Dioleoyl-3(S)-trimethylammoniumpropane chloride -
Similarity Score 0.87
HY-W800776DORI -
Similarity Score 0.86
HY-142995DODAP hydrochloride -
Similarity Score 0.86
HY-130751DODAP -
Similarity Score 0.85
HY-164283DOCP -
Similarity Score 0.83
HY-115767(±)-1,2-Diolein -
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References
- [1]. Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes. Biochim Biophys Acta. 2015 Oct;1848 (10 Pt A) :1996-2001. [Content Brief]
- [2]. Crook K, et al. Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum. Gene Ther. 1998 Jan;5 (1) :137-43. [Content Brief]
