1190197-97-7
1190197-97-7
Chemical Structure
DLin-KC2-DMA
- CAS No.: 1190197-97-7
- Formula:C43H79NO2
- Molecular Weight:642.09
IUPAC Name: 2-(2,2-di((9Z,12Z)-octadeca-9,12-dien-1-yl)-1,3-dioxolan-4-yl)-N,N-dimethylethan-1-amine
InChIKey: LRFJOIPOPUJUMI-KWXKLSQISA-N
SMILES: CCCCC/C=C\C/C=C\CCCCCCCCC1(CCCCCCCC/C=C\C/C=C\CCCCC)OC(CCN(C)C)CO1
Biological Activity: DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies[1][2].
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DLin-KC2-DMA | 99.88% | DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.94
HY-145225DLin-K-C3-DMA -
Similarity Score 0.91
HY-153852LNP Lipid-7 -
Similarity Score 0.76
HY-147087YSK 05 -
Similarity Score 0.74
HY-154803DLin-M-K-DMA -
Similarity Score 0.74
HY-112251GLD-Lin-MC3-DMA (GMP Like) -
Similarity Score 0.73
HY-112757DLinDMA -
Similarity Score 0.73
HY-185010nor-MC3 -
Similarity Score 0.72
HY-154804DLin-M-C4-DMA -
Similarity Score 0.72
HY-160852YSK 12C4 -
Explore the MedChemAI to find more analogs
References
- [1]. Basha G, et al. Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol Ther. 2011 Dec;19(12):2186-200. [Content Brief]
- [2]. Miller AD, et al. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. [Content Brief]
