1857341-90-2
Chemical Structure
5A2-SC8
- CAS No.: 1857341-90-2
- Formula:C93H173N5O20S5
- Molecular Weight:1841.72
IUPAC Name: 5H-imidazo[5,1-a]isoindole
InChIKey: BYWPQQOQVPVCTC-UHFFFAOYSA-N
SMILES: O=C(CCN(CCNCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCNCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCCC)C)=O
Biological Activity: 5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models[1][2][3].
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5A2-SC8 | 99.89% | 5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models. | ||||||||||||||||||||
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- [1]. Zhou K, Nguyen LH, Miller JB, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016;113(3):520-525. [Content Brief]
- [2]. Johnson, et al. "Lipid nanoparticle (LNP) chemistry can endow unique in vivo RNA delivery fates within the liver that alter therapeutic outcomes in a cancer model." Molecular pharmaceutics 19.11 (2022): 3973-3986. [Content Brief]
- [3]. Johnson, et al. The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes. Diss. 2022.
Keywords
