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4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model.

For research use only. We do not sell to patients.

4A3-SC8 Chemical Structure

4A3-SC8 Chemical Structure

CAS No. : 1857340-78-3

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5 mg USD 300 In-stock
10 mg USD 490 In-stock
25 mg USD 980 In-stock
50 mg USD 1600 In-stock
100 mg USD 2580 In-stock
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Based on 1 publication(s) in Google Scholar

4A3-SC8 Related Antibodies

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Description

4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model[1].

In Vivo

4A3-SC8 mediates siRNA accumulation mainly in liver and slightly in the spleen and kidneys 24 hours after intravenous injection at dosage of 1 mg siRNA/kg and enables >95% FVII knockdown in mice[1].
After injection with 4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once), mice became sick and lost nearly 20% of their weight on the first day postinjection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1467.18

Formula

C75H139N3O16S4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)C)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCCC)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (68.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6816 mL 3.4079 mL 6.8158 mL
5 mM 0.1363 mL 0.6816 mL 1.3632 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (239 KB) HNMR (119 KB) LCMS (420 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6816 mL 3.4079 mL 6.8158 mL 17.0395 mL
5 mM 0.1363 mL 0.6816 mL 1.3632 mL 3.4079 mL
10 mM 0.0682 mL 0.3408 mL 0.6816 mL 1.7039 mL
15 mM 0.0454 mL 0.2272 mL 0.4544 mL 1.1360 mL
20 mM 0.0341 mL 0.1704 mL 0.3408 mL 0.8520 mL
25 mM 0.0273 mL 0.1363 mL 0.2726 mL 0.6816 mL
30 mM 0.0227 mL 0.1136 mL 0.2272 mL 0.5680 mL
40 mM 0.0170 mL 0.0852 mL 0.1704 mL 0.4260 mL
50 mM 0.0136 mL 0.0682 mL 0.1363 mL 0.3408 mL
60 mM 0.0114 mL 0.0568 mL 0.1136 mL 0.2840 mL
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4A3-SC8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4A3-SC81857340-78-3Othersdegradable dendrimersmall RNAliver cancerInhibitorinhibitorinhibit

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