DSPE-PEG5000-Biotin
DSPE-PEG5000-Biotin is a biotin-labeled PEG derivative composed of phospholipid (DSPE), a hydrophilic polyethylene glycol chain (PEG5000) and a biotin tag. DSPE-PEG5000-Biotin is widely used in scientific research for constructing targeted liposomes, micelles and lipid nanoparticles for drug delivery and cell binding experiments.
For research use only. We do not sell to patients.
- CAS No.: 385437-57-0
- Molecular Weight:5000 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-140736
DSPE-PEG2000-Biotin
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HY-125924
DSPE-PEG-Amine, MW 2000 ammonium
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HY-140736A
DSPE-PEG1000-Biotin
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HY-W440823A
DSPE-PEG1000-Amine ammonium
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HY-112530
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine
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HY-112764
mPEG2000-DMG
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HY-138300
ALC-0159
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HY-144006
DMPE-PEG2000 ammonium
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HY-144013
18:0 mPEG2000 PE ammonium
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HY-144013H
18:0 mPEG5000 PE ammonium
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HY-112764GL
mPEG2000-DMG (GMP Like)
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HY-125924A
DSPE-PEG20000-Amine ammonium
Biological Activity
DSPE-PEG-Biotin promotes the targeted delivery of the biotin-directed Salinomycin (HY-15597) (DTSS) nanoplatform to the tumor microenvironment, enhances cellular uptake of nanoparticle payloads, and improves the surface hydrophilicity and stability of nanoparticles[1].
DSPE-PEG-Biotin enables targeted accumulation of the assembled aggregation-induced emission (AIE)/Biotin-M micelles in tumor cells/tissues without impairing the micelles' sonosensitivity or AIE properties; meanwhile, it enhances the internalization of micelles by 4T1 tumor cells, and this uptake process can be inhibited by pre-treated free biotin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 385437-57-0
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Molecular Weight 5000 (Average)
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SMILES
CCCCCCCCCCCCCCCCCC(O[C@](COP(OCCNC(COCCOCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)=O)(O[Na])=O)([H])COC(CCCCCCCCCCCCCCCCC)=O)=O.[MW 5000].[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang L, et al. Self-assembly driven nano-salinomycin for high-efficiency cancer immunotherapy by reticulum stress mediated stemness suppression. Biomaterials. 2026 Feb;325:123632. [Content Brief]
[2]. Deng K, et al. Tumor-targeted AIE polymeric micelles mediated immunogenic sonodynamic therapy inhibits cancer growth and metastasis. Nanoscale. 2023 May 04;15(17):8006-8018. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG5000-Biotin Related Classifications
HY-140736B Related Classifications
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- DSPE-PEG5000-Biotin
- 385437-57-0
- Biochemical Assay Reagents
- Liposome
- singlet oxygen
- reactive oxygen species
- tumor cell surface integrins
- 4T1 tumor
- immunogenic cell death
- tumor microenvironment
- anti-angiogenic effects
- systemic antitumor immune activation
- breast cancer
- 4T1 breast cancer cells
- Inhibitor
- inhibitor
- inhibit