Liposome
Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.
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Liposome Related Products (1266)
Related Products (1266)
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1,2-Distearoyl-sn-glycero-3-phosphate sodium
0 Images1,2-Distearoyl-sn-glycero-3-phosphate, sodium salt is a phospholipid commonly used as a component of liposome formulations and drug delivery systems. 1,2-Distearoyl-sn-glycero-3-phosphate, sodium salt has unique chemical properties that make it an effective tool for encapsulating drugs and delivering them to specific targets in the body. It acts as a stabilizer and emulsifier, which can improve the solubility and bioavailability of drugs.
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DSPE-PEG2000-TCO
0 ImagesDSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis.
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N,N',N''-Triacetylchitotriose
0 ImagesN,N',N''-Triacetylchitotriose is a competitive Lysozyme inhibitor. N,N',N''-Triacetylchitotriose inhibits the activity of lysozyme. N,N',N''-Triacetylchitotriose reduces the fusion rate between lysozyme-conjugated liposomes and erythrocyte ghosts, and decreases the equilibrium fusion rate.
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1-Palmitoyl-2-linoleoyl-sn-glycero-3-PE
0 ImagesSynonyms: 1-Palmitoyl-2-linoleoyl PE; (1-Palmitoyl, 2-linoleoyl)-phosphatidylethanolamine; (1-Palmitoyl, 2-linoleoyl)-phosphoethanolamine1-Palmitoyl-2-linoleoyl-sn-glycero-3-PE (1-Palmitoyl-2-linoleoyl PE; (1-Palmitoyl, 2-linoleoyl)-phosphatidylethanolamine; (1-Palmitoyl, 2-linoleoyl)-phosphoethanolamine) is a phosphatidylethanolamine phospholipid with a palmitoyl chain at sn-1 and a linoleoyl chain at sn-2, and an oxidation-prone substrate. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PE undergoes glycation and subsequent oxidation via Fenton system, forming long-chain and short-chain products at C-7, C-8, C-9, C-12 of its sn-2 acyl chain and glycated polar head. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PE’s glycated form oxidizes more quickly than non-glycated phosphatidylethanolamines and contributes to increased oxidative stress modifications. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PE can be used for the research of drug delivery.
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Distearoylphosphatidylserine sodium
0 ImagesSynonyms: DSPS sodiumDistearoylphosphatidylserine (DSPS) sodium is an anionic phospholipid. Distearoylphosphatidylserine sodium possesses both a hydrophilic head group and a hydrophobic tail, enabling it to self-assemble in aqueous phases to form stable lipid bilayer structures. Distearoylphosphatidylserine sodium promotes uptake by phagocytes and participates in the endosomal escape of lipid nanoparticles (LNPs) within cells. Distearoylphosphatidylserine sodium can be used in research on the construction of lipid nanoparticles for targeted delivery of siRNA (for immune or anti-inflammatory therapy), as well as the preparation of ultrasound contrast microbubbles for molecular imaging.
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DPyPE
0 ImagesDPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane.
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DSPE-PEG2000-T7
0 ImagesCat. No.: HY-172723DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease.
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SQDG
0 ImagesSQDG inhibits topoisomerase I and P-selectin receptor, exhibits anti-inflammatory, antiviral and antitumor activities. SQDG is a glycolipid that possesses sugar moieties in their head groups. SQDG is a membrane lipid that can be used to investigate the effects of structural lipid in LNP formulations.
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DOPE-Mal
0 ImagesDOPE-Mal is an N-maleimide-derived phosphatidylethanolamine. DOPE-Mal does not interfere with fatty acyl chains or alter lipid bilayer permeability; it increases lipid bilayer order, reduces fluidity, induces conformational changes in phospholipid polar heads and enhances their hydration. DOPE-Mal can be used as a component to prepare maleimide-displaying liposomes, enabling peptide conjugation via maleimide-thiol coupling. DOPE-Mal can be used to prepare Liposomes for delivering Doxorubicin (HY-15142A) to hepatocytes. DOPE-Mal is applicable to research related to hepatocellular carcinoma and lung cancer.
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DPPE-PEG2000 ammonium
0 ImagesSynonyms: 16:0 PEG2000 PE ammonium; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammoniumDPPE-PEG2000 ammonium (16:0 PEG5000 PE) is a polymer-lipid conjugate and LipoParticle stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG2000 ammonium enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG2000 ammonium helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG2000 ammonium serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections.
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DSPE-Biotin
0 ImagesCat. No.: HY-W441000CAS No.: 133695-76-8DSPE-Biotin is a lipid. DSPE-Biotin can be used for the research of various biochemical.
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DOPE-NHS
0 ImagesCat. No.: HY-150241CAS No.: 1010188-79-0DOPE-NHS is a linker. DOPE-NHS can be used for peptides to be conjugated to exosomes and possibly other membrane-based nanoparticles. DOPE-NHS can be used for drug delivery.
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DSPE-PEG3400-Maleimide ammonium
0 ImagesCat. No.: HY-W441009ADSPE-PEG3400-Maleimide ammonium has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG3400-Maleimide ammonium can be used in drug delivery research.
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BAMEA-O16B
0 ImagesBAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing.
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1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate sodium
0 ImagesSynonyms: 16:0-18:1 PA sodium1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate (16:0-18:1 PA) sodium is an anionic phospholipid containing a monounsaturated acyl chain. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate sodium exhibits activity in modulating biological membrane fluidity and participating in cell signal transduction. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate sodium is used in the preparation of micelles, liposomes, and other types of artificial membranes.
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1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate
0 Images1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a carboxylic acid lipid targeting agent. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate serves as a carboxylic acid lipid substitute for phosphatidylserine and is used to control liposome surface modification, and the modified liposomes exhibit in vivo compound release behavior similar to that of unmodified liposomes. Liposomes containing 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate specifically target bone marrow. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is used in the study of breast cancer.
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OF-C4-Deg-Lin
0 ImagesOF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA.
