Vaxfectin
Based on 1 Customer Validation
Vaxfectin is a second-generation cationic lipid-based suspension that adjuvants effectively both pDNA and protein-based vaccines. Vaxfectin can boost the immune response against a range of pDNA-expressed pathogenic antigens in vivo. Vaxfectin can increase IgG titers and give rise to an IL-6 dependent enhancement of the humoral immune response without altering the Th1 type immune response. Vaxfectin can be studied for vaccine formulation.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 370108-99-9
- Formula: C81H163BrN3O10P
- Molecular Weight:1450.05
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Vaxfectin (i.m., single dose) formulated VR4700 (25 μg per muscle) results in stronger CTL responses in mice[2].
Vaxfectin (i.m., single dose) formulated VR4700 (5 μg) increases the number of antigen-specific plasma cells in bone marrow[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 370108-99-9
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Appearance Oil
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Molecular Weight 1450.05
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Formula C81H163BrN3O10P
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Color Light yellow to yellow
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SMILES
NCCOP(OC[C@H](OC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)COC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)(O)=O.CCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)CCCN)OCCCCCCCC/C=C\CCCC.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (68.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sullivan SM, et, al. Vaxfectin: a versatile adjuvant for plasmid DNA- and protein-based vaccines. Expert Opin Drug Deliv. 2010 Dec;7(12):1433-46. [Content Brief]
[2]. Hartikka, J., et al., (2001). Vaxfectin enhances the humoral immune response to plasmid DNA-encoded antigens. Vaccine, 19(15-16), 1911–1923. [Content Brief]
[3]. Reyes, L., et al., (2001). Vaxfectin enhances antigen specific antibody titers and maintains Th1 type immune responses to plasmid DNA immunization. Vaccine, 19(27), 3778–3786. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6896 mL | 3.4482 mL | 6.8963 mL | 17.2408 mL |
| 5 mM | 0.1379 mL | 0.6896 mL | 1.3793 mL | 3.4482 mL | |
| 10 mM | 0.0690 mL | 0.3448 mL | 0.6896 mL | 1.7241 mL | |
| 15 mM | 0.0460 mL | 0.2299 mL | 0.4598 mL | 1.1494 mL | |
| 20 mM | 0.0345 mL | 0.1724 mL | 0.3448 mL | 0.8620 mL | |
| 25 mM | 0.0276 mL | 0.1379 mL | 0.2759 mL | 0.6896 mL | |
| 30 mM | 0.0230 mL | 0.1149 mL | 0.2299 mL | 0.5747 mL | |
| 40 mM | 0.0172 mL | 0.0862 mL | 0.1724 mL | 0.4310 mL | |
| 50 mM | 0.0138 mL | 0.0690 mL | 0.1379 mL | 0.3448 mL | |
| 60 mM | 0.0115 mL | 0.0575 mL | 0.1149 mL | 0.2873 mL |
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