DOPE-NHS
Based on 1 Customer Validation
DOPE-NHS is a linker. DOPE-NHS can be used for peptides to be conjugated to exosomes and possibly other membrane-based nanoparticles. DOPE-NHS can be used for drug delivery.
For research use only. We do not sell to patients.
- Purity: 92.0%
- CAS No.: 1010188-79-0
- Formula: C50H87N2O13P
- Molecular Weight:955.21
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Storage:
RT, sealed storage, away from moisture and light.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
The use of DOPE-NHS allows for peptides to be conjugated to exosomes and possibly other membrane-based nanoparticles[1].
MSC derived exosomes are conjugated with rabies viral glycoprotein through a DOPE-NHS linker[1].
Exosomes are conjugated with cardiac homing peptide through a DOPE-NHS linker[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1010188-79-0
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Appearance Oil
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Molecular Weight 955.21
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Formula C50H87N2O13P
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Color Colorless to off-white
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SMILES
CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCNC(CCCC(ON1C(CCC1=O)=O)=O)=O)(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, sealed storage, away from moisture and light
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMSO : 25 mg/mL (26.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Cui GH, et al. RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's disease. Immun Ageing. 2019 May 13;16:10. [Content Brief]
[2]. Vandergriff A, et al. Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide. Theranostics. 2018 Feb 14;8(7):1869-1878. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0469 mL | 5.2345 mL | 10.4689 mL | 26.1723 mL |
| 5 mM | 0.2094 mL | 1.0469 mL | 2.0938 mL | 5.2345 mL | |
| 10 mM | 0.1047 mL | 0.5234 mL | 1.0469 mL | 2.6172 mL | |
| 15 mM | 0.0698 mL | 0.3490 mL | 0.6979 mL | 1.7448 mL | |
| 20 mM | 0.0523 mL | 0.2617 mL | 0.5234 mL | 1.3086 mL | |
| 25 mM | 0.0419 mL | 0.2094 mL | 0.4188 mL | 1.0469 mL |
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