VC1052
Based on 1 Customer Validation
VC1052 is a dialkoxypropylammonium-based material and is the core cationic lipid component of the cationic lipid adjuvant Vaxfectin (HY-142998). Vaxfectin consists of VC1052 and lipid DPyPE (HY-112766) in a 1:1 molar ratio. Vaxfectin can be used as a vaccine adjuvant for the preparation of plasmid DNA and protein vaccines.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 370108-98-8
- Formula: C36H73BrN2O2
- Molecular Weight:645.88
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
VC1052 has a similar structure to GAP-DLRIE and DMRIE, and is a member of the dialkoxypropylamine cationic lipid class[1].
GAP-DLRIE is primarily used to enhance gene transfection efficiency in local tissues (e.g., lungs), but VC1052 does not enhance pDNA transfection in muscle tissue when it forms a complex with the neutral lipid DPyPE at a 1:1 molar ratio. However, it significantly enhances humoral immune responses (antibody titers increased by 20-50 times) by promoting pDNA uptake by antigen presenting cells (APCs) and inducing cytokine secretion (e.g., IL-6) [1].
GAP-DLRIE significantly enhances the delivery efficiency and gene expression level of pDNA in specific tissues (e.g., mouse lungs) by forming a lipoplex with plasmid DNA (pDNA). GAP-DLRIE relies on cationic lipids to bind to the negatively charged phosphate backbone of DNA to form a stable complex that promotes cellular uptake of DNA and protects DNA from nuclease degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 370108-98-8
-
Appearance Liquid
-
Molecular Weight 645.88
-
Formula C36H73BrN2O2
-
Color Colorless to light yellow
-
SMILES
CCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)CCCN)OCCCCCCCC/C=C\CCCC.[Br-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (154.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (265 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5483 mL | 7.7414 mL | 15.4828 mL | 38.7069 mL |
| 5 mM | 0.3097 mL | 1.5483 mL | 3.0966 mL | 7.7414 mL | |
| 10 mM | 0.1548 mL | 0.7741 mL | 1.5483 mL | 3.8707 mL | |
| 15 mM | 0.1032 mL | 0.5161 mL | 1.0322 mL | 2.5805 mL | |
| 20 mM | 0.0774 mL | 0.3871 mL | 0.7741 mL | 1.9353 mL | |
| 25 mM | 0.0619 mL | 0.3097 mL | 0.6193 mL | 1.5483 mL | |
| 30 mM | 0.0516 mL | 0.2580 mL | 0.5161 mL | 1.2902 mL | |
| 40 mM | 0.0387 mL | 0.1935 mL | 0.3871 mL | 0.9677 mL | |
| 50 mM | 0.0310 mL | 0.1548 mL | 0.3097 mL | 0.7741 mL | |
| 60 mM | 0.0258 mL | 0.1290 mL | 0.2580 mL | 0.6451 mL | |
| 80 mM | 0.0194 mL | 0.0968 mL | 0.1935 mL | 0.4838 mL | |
| 100 mM | 0.0155 mL | 0.0774 mL | 0.1548 mL | 0.3871 mL |
Powered by Bioz