Glyceryl monostearate
Based on 1 Customer Validation
Glyceryl monostearate (GMS) is a type of monoglyceride. Glyceryl monostearateGlyceryl monostearate can serve as a core lipid material for constructing solid lipid nanoparticles in the field of drug delivery. Glyceryl monostearate can be used as a gelling agent to structure liquid vegetable oils into semi-solid oleogels, so as to replace animal fat in meat products.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 31566-31-1
- Formula: C21H42O4
- Molecular Weight:358.56
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Lipid Compound Library
HY-L043
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Liposome Library
HY-L214
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
>100 μM
Compound: 8
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Cytotoxicity against human LNCAP cells after 48 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 48 hrs by MTT assay
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[PMID: 11858758] |
| NUGC-3 | IC50 |
100 μM
Compound: MG
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Cytotoxicity against human NUGC-3 cells assessed as cell growth inhibition incubated for 30 mins by MTT assay
Cytotoxicity against human NUGC-3 cells assessed as cell growth inhibition incubated for 30 mins by MTT assay
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[PMID: 29126728] |
Glyceryl monostearate is used in solid lipid nanoparticles for the controlled-release delivery of Docetaxel (HY-B0011) to enhance its therapeutic efficacy, and these nanoparticles can be applied to research on breast cancer and ovarian cancer[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 31566-31-1
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Appearance Solid
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Molecular Weight 358.56
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Formula C21H42O4
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCC(OCC(CO)O)=O
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Synonyms
GMS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (278.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (265 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Ferro AC, et al. Glyceryl monostearate-based oleogels as a new fat substitute in meat emulsion. Meat Sci. 2021;174:108424. [Content Brief]
[2].
Rai N, et al. Glyceryl Monostearate based Solid Lipid Nanoparticles for Controlled Delivery of Docetaxel. Curr Drug Deliv. 2021;18(9):1368-1376.
[Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7889 mL | 13.9447 mL | 27.8893 mL | 69.7233 mL |
| 5 mM | 0.5578 mL | 2.7889 mL | 5.5779 mL | 13.9447 mL | |
| 10 mM | 0.2789 mL | 1.3945 mL | 2.7889 mL | 6.9723 mL | |
| 15 mM | 0.1859 mL | 0.9296 mL | 1.8593 mL | 4.6482 mL | |
| 20 mM | 0.1394 mL | 0.6972 mL | 1.3945 mL | 3.4862 mL | |
| 25 mM | 0.1116 mL | 0.5578 mL | 1.1156 mL | 2.7889 mL | |
| 30 mM | 0.0930 mL | 0.4648 mL | 0.9296 mL | 2.3241 mL | |
| 40 mM | 0.0697 mL | 0.3486 mL | 0.6972 mL | 1.7431 mL | |
| 50 mM | 0.0558 mL | 0.2789 mL | 0.5578 mL | 1.3945 mL | |
| 60 mM | 0.0465 mL | 0.2324 mL | 0.4648 mL | 1.1621 mL | |
| 80 mM | 0.0349 mL | 0.1743 mL | 0.3486 mL | 0.8715 mL | |
| 100 mM | 0.0279 mL | 0.1394 mL | 0.2789 mL | 0.6972 mL |
Glyceryl monostearate Related Classifications
HY-151226 Related Classifications
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