2. Vías de señalización
  3. Cell Cycle/DNA Damage
  4. Microphthalmia Associated Transcription Factor (MITF)
  5. Microphthalmia Associated Transcription Factor (MITF) Inhibitor

Microphthalmia Associated Transcription Factor (MITF) Inhibitor

Microphthalmia Associated Transcription Factor (MITF) Inhibitors (3):

Cat. No. Nombre del producto Efecto Pureza
  • HY-101464
    ML329
    		Inhibitor 98.0%
    ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM.
  • HY-156483
    TT-012
    		Inhibitor 99.76%
    TT-012 is a MITF inhibitor with a human MITF IC50 of 13.1 nM and a human MITF Kd value of 15.5 nM. TT-012 reduces mRNA levels of MITF downstream genes linked to melanosome biogenesis, cell survival, and proliferation, and upregulates cell cycle-inhibiting genes. TT-012 can be used for the research of melanoma[1][2][3].
  • HY-120996
    10(E)-Pentadecenoic acid
    		Inhibitor 99.90%
    10 (E)-Pentadecenoic acid (trans-10-Pentadecenoic acid) is a melanin synthesis inhibitor. 10 (E)-Pentadecenoic acid inhibits nuclear translocation and reduces the protein level of phosphorylated microphthalmia-associated transcription factor (MITF), as well as decreases intracellular tyrosinase activity. 10 (E)-Pentadecenoic acid can be used in the research of skin pigmentation disorders.