1164471-33-3
1164471-33-3
Chemical Structure
TT-012
- CAS No.: 1164471-33-3
- Formula:C19H15N3O4
- Molecular Weight:349.34
InChIKey: YUFJMFXVUUMVCA-GFULKKFKSA-N
SMILES: O=C(/C=C/C1=CC=CO1)NC2=CC=CC(NC(/C=C/C3=CC=CO3)=O)=N2
Biological Activity: TT-012 is a MITF inhibitor with a human MITF IC50 of 13.1 nM and a human MITF Kd value of 15.5 nM. TT-012 reduces mRNA levels of MITF downstream genes linked to melanosome biogenesis, cell survival, and proliferation, and upregulates cell cycle-inhibiting genes. TT-012 can be used for the research of melanoma[1][2][3].
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TT-012 | 99.76% | TT-012 is a MITF inhibitor with a human MITF IC50 of 13.1 nM and a human MITF Kd value of 15.5 nM. TT-012 reduces mRNA levels of MITF downstream genes linked to melanosome biogenesis, cell survival, and proliferation, and upregulates cell cycle-inhibiting genes. TT-012 can be used for the research of melanoma. | ||||||||||||||||||||
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Keywords
