α-Synuclein inhibitor 8
Based on 1 publication(s) in Google Scholar
α-Synuclein inhibitor 8 is an active inhibitor of α-Synuclein with an IC50 value of 2.5 µM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD)-like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 2883627-64-1
- Formula: C24H20N2O6
- Molecular Weight:432.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) α-Synuclein inhibitor 8
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Biological Activity
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α-synuclein Aggregation |
α-Synuclein inhibitor 8 (Compound 2ee) (0-100 μM; 0-96 h) inhibits the aggregation of α-Synuclein in a dose-dependent manner[1].
α-Synuclein inhibitor 8 (100 µM; 48 h) decomposes mature fiber into soluble protein and a small amount of short insoluble fiber[1].
α-Synuclein inhibitor 8 (1-1000 µM; 0.5 h or 24 h) increases the clearance rate of reactive oxygen species in a dose-dependent manner. α-Synuclein inhibitor 8 has low cytotoxicity to H4 and SH-SY5Y cells (cell viability is higher than 80%)[1].
α-Synuclein inhibitor 8 (10 µM; 38 h) has inhibitory effect on α-Synuclein aggregation and inclusion body formation in H4 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H4 and SH-SY5Y cells.
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Concentration:1, 3, 10, 30, 100, 300, 500 and 1000 µM.
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Incubation Time:24 h.
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Result:Showed low cytotoxicity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-OHDA-lesioned C57 mice model of PD (8-12 weeks, 20-28 g)[1].
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Dosage:0.9 μg/μL.
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Administration:Intravenous injection (right striatum); single dose.
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Result:Exhibited neuroprotective and repair effects.
Chemical Information
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CAS No. 2883627-64-1
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Molecular Weight 432.43
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Formula C24H20N2O6
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SMILES
OC1=CC=C(O)C=C1/C=C/C(NC2=CC=C(NC(/C=C/C3=CC(O)=CC=C3O)=O)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Adv Res
Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson's disease. [Abstract]2025 May 25:S2090-1232(25)00370-4. PMID: 40425084
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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