100403-24-5
Chemical Structure
PDRN
Synonym(s): Polydeoxyribonucleotide
- CAS No.: 100403-24-5
- Formula:N/A
- Molecular Weight:N/A
SMILES: [PDRN]
Biological Activity: PDRN (Polydeoxyribonucleotide) is a deoxynucleotide polymer mainly derived from the sperm of rainbow trout or salmon. PDRN inhibits pro-inflammatory factors and promotes VEGF expression via the cAMP-PKA pathway by activating the adenosine A2A receptor (A2AR), thereby driving angiogenesis and collagen deposition in fibroblasts. Degradation products of PDRN provide DNA raw materials for proliferating cells through the salvage synthesis pathway, accelerating re-epithelialization. PDRN reduces melanin synthesis and cell apoptosis by upregulating ERK/AKT phosphorylation and inhibiting the activities of MITF and tyrosinase, and resists skin aging by attenuating nuclear autophagy and blocking the interaction between LC3-SIRT1. PDRN is mainly used for wound repair, post-aesthetic surgery recovery and anti-aging research[1][2][3][4].
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PDRN | 90.2% | PDRN (Polydeoxyribonucleotide) is a deoxynucleotide polymer mainly derived from the sperm of rainbow trout or salmon. PDRN inhibits pro-inflammatory factors and promotes VEGF expression via the cAMP-PKA pathway by activating the adenosine A2A receptor (A2AR), thereby driving angiogenesis and collagen deposition in fibroblasts. Degradation products of PDRN provide DNA raw materials for proliferating cells through the salvage synthesis pathway, accelerating re-epithelialization. PDRN reduces melanin synthesis and cell apoptosis by upregulating ERK/AKT phosphorylation and inhibiting the activities of MITF and tyrosinase, and resists skin aging by attenuating nuclear autophagy and blocking the interaction between LC3-SIRT1. PDRN is mainly used for wound repair, post-aesthetic surgery recovery and anti-aging research. | ||||||||||||||||||||
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- [1]. Squadrito F, et al. Pharmacological Activity and Clinical Use of PDRN. Frontiers in pharmacology. 2017;8:224. [Content Brief]
- [2]. Noh TK, et al. Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster. International journal of molecular sciences. 2016 Sep 01;17(9):1448. [Content Brief]
- [3]. Chen J, et al. PDRN prevents SIRT1 degradation by attenuating autophagy during skin aging. PloS one. 2025;20(5):e0321005. [Content Brief]
- [4]. Flores Rodríguez JC, et al. Polydeoxyribonucleotide (PDRN) in Post-procedure Recovery in Aesthetic Medicine: A Narrative Review. Cureus. 2026 May;18(5):e108886. [Content Brief]
Keywords
