A3AR antagonist-8
A3AR antagonist-8 is a selective A3 adenosine receptor antagonist with a Ki of 98 nM for human A3 adenosine receptor. A3AR antagonist-8 can be used for the research of glaucoma, chronic renal disease, acute renal ischemia and reperfusion injury, and cancer.
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- Formel: C17H12N6O3
- Molecular Weight:348.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
human A3 98 nM (Ki) |
In Vitro
A3AR antagonist-8 (Compound 40) exhibits potent, selective binding to human A3 adenosine receptors (hA3R) with a Ki of 98 nM, while showing no quantifiable binding to human A1 adenosine receptors (hA1R; Ki > 32 μM)[1].
A3AR antagonist-8 (10 μM) acts as an antagonist for human A3 adenosine receptors (hA3R) and exhibits ~6-fold and ~43-fold selectivity for hA3R over human A2A and A2B adenosine receptors, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 348.32
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Formel C17H12N6O3
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SMILES
O=[N+](C1=CC=C(C2=NNC3=C(NC4=CC=C(O)C=C4)N=CN=C32)C=C1)[O-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
A3AR antagonist-8 Related Classifications
HY-183993 Related Classifications
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