A3AR antagonist-8
A3AR antagonist-8 is a selective A3 adenosine receptor antagonist with a Ki of 98 nM for human A3 adenosine receptor. A3AR antagonist-8 can be used for the research of glaucoma, chronic renal disease, acute renal ischemia and reperfusion injury, and cancer.
For research use only. We do not sell to patients.
- Formula: C17H12N6O3
- Molecular Weight:348.32
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Adenosine Receptor Isoforms
More
Biological Activity
|
human A3 98 nM (Ki) |
A3AR antagonist-8 (Compound 40) exhibits potent, selective binding to human A3 adenosine receptors (hA3R) with a Ki of 98 nM, while showing no quantifiable binding to human A1 adenosine receptors (hA1R; Ki > 32 μM)[1].
A3AR antagonist-8 (10 μM) acts as an antagonist for human A3 adenosine receptors (hA3R) and exhibits ~6-fold and ~43-fold selectivity for hA3R over human A2A and A2B adenosine receptors, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 348.32
-
Formula C17H12N6O3
-
SMILES
O=[N+](C1=CC=C(C2=NNC3=C(NC4=CC=C(O)C=C4)N=CN=C32)C=C1)[O-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz