Art. -Nr.: HY-128387

2,3-Butanediol

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2,3-Butanediol is microbially derived compound that is a discriminating urinary biomarker of Fmo5^-/- mice. 2,3-Butanediol prevents age-related increases in the plasma concentration of cholesterol. 2,3-Butanediol has potential applications in the manufacture of printing inks, perfumes, fumigants, moistening and softening agents, plasticizers, and as a carrier for pharmaceuticals.

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Reinheit: 99.96%
CAS. Nr.: 513-85-9
Formel: C₄H₁₀O₂
Molecular Weight:90.12

Speicherung:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

2,3-Butanediol Chemical Structure

CAS. Nr.: 513-85-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

2,3-Butanediol contains two stereo centers, resulting in three stereo isomers including (2R,3R)-, meso- and (2S,3S)-forms^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

2,3-Butanediol isomer mix (60-600 mg/kg/d; orally in drinking water; for 4 weeks) prevents age-related increases in the plasma concentration of cholesterol and reduces the deposition of epididymal fat^[2].
Short- (4-week) and long-term (14-week) treatment of wild-type mice with a 2,3-Butanediol isomer mix decrease plasma cholesterol and epididymal fat deposition but have no effect on plasma concentrations of glucose or insulin, or on body weight. In the case of long-term treatment, the effects are maintained after withdrawal of 2,3-Butanediol. Short-, but not long-term treatment, also decreases plasma concentrations of triglycerides and non-esterified fatty acids^[2].
The isomers of 2,3-Butanediol are discriminating urinary biomarkers of Fmo5^-/- mice. Antibiotic treatment of Fmo5^-/- mice increased plasma cholesterol concentrations and substantially reduced urinary excretion of 2,3-Butanediol, showing that gut bacteria contribute to the lower plasma cholesterol of Fmo5^−/− mice, and that 2,3-Butanediol is microbially derived^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wild-type mice (aged 13 weeks)^[2]
Dosage:

60 mg/kg/d, 250 mg/kg/d or 600 mg/kg/d (4:1:1 ratio of meso-2,3-Butanediol : 2R,3R-Butanediol : 2S,3S-Butanediol)
Administration:

Orally in drinking water; for 4 weeks
Result:

At a dose of 250 mg/kg/d, plasma concentrations of both total cholesterol and HDL cholesterol were significantly lower than those of mice that were untreated for 4 weeks.
At doses of 60 or 600 mg/kg/d did not prevent age-related increases in plasma concentrations of either total or HDL cholesterol.

Chemical Information

CAS. Nr. 513-85-9
Appearance Liquid (Density: 1.002 g/cm³)
Molecular Weight 90.12
Formel C₄H₁₀O₂
Color Colorless to off-white
SMILES

CC(O)C(O)C
Structure Classification
- Others
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Escherichia coli
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (1109.63 mM; Need ultrasonic)

DMSO : 100 mg/mL (1109.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

11.0963 mL

55.4816 mL

110.9632 mL

5 mM

2.2193 mL

11.0963 mL

22.1926 mL

10 mM

1.1096 mL

5.5482 mL

11.0963 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (27.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (27.74 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (27.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 140 mg/mL (1553.48 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (255 KB)
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- Portuguese - PT (255 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang L, et al. Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241. Sci Rep. 2016 Jan 12;6:19257. [Content Brief]

[2]. Veeravalli S, et al. Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5-/- mice, decreases plasma cholesterol and epididymal fat deposition. Front Physiol. 2022 Aug 8;13:859681. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	11.0963 mL	55.4816 mL	110.9632 mL	277.4079 mL
	5 mM	2.2193 mL	11.0963 mL	22.1926 mL	55.4816 mL
	10 mM	1.1096 mL	5.5482 mL	11.0963 mL	27.7408 mL
	15 mM	0.7398 mL	3.6988 mL	7.3975 mL	18.4939 mL
	20 mM	0.5548 mL	2.7741 mL	5.5482 mL	13.8704 mL
	25 mM	0.4439 mL	2.2193 mL	4.4385 mL	11.0963 mL
	30 mM	0.3699 mL	1.8494 mL	3.6988 mL	9.2469 mL
	40 mM	0.2774 mL	1.3870 mL	2.7741 mL	6.9352 mL
	50 mM	0.2219 mL	1.1096 mL	2.2193 mL	5.5482 mL
	60 mM	0.1849 mL	0.9247 mL	1.8494 mL	4.6235 mL
	80 mM	0.1387 mL	0.6935 mL	1.3870 mL	3.4676 mL
	100 mM	0.1110 mL	0.5548 mL	1.1096 mL	2.7741 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2,3-Butanediol

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

2,3-Butanediol Related Classifications

HY-128387 Related Classifications