CCR7

CCR7 is a CC chemokine receptor that organizes primary immune responses by positioning T cells and dendritic cells within secondary lymphoid organs^[1]. Mechanistically, CCL19 and CCL21 activate CCR7 to guide lymph-node homing, dendritic-cell migration, and T-cell priming^[2][3]. In disease models, CCR7 supports melanoma lymph-node metastasis and CNS infiltration in T-cell leukemia, showing its relevance to tumor dissemination research^[4][5]. Compared with related chemokine-receptor axes, CCR7 is defined by its paired ligands CCL19/CCL21 and their biased signaling, because CCL19 strongly promotes arrestin-mediated receptor endocytosis whereas CCL21 does not^[6][7]. For experimental applications, anti-CCR7 antibodies reduced mantle-cell lymphoma growth and dissemination in xenograft models, supporting CCR7 blockade as a research tool for migration-dependent malignancy models^[8].