GSK575594A
GSK575594A is a modulator of the nicotinic acetylcholine receptor (nAChR) in Ascaris suum. GSK575594A enhances muscle contractions induced by acetylcholine (ACh) by binding to the allosteric binding site between subunits within the transmembrane domain of nAChR. At a concentration of 3 μM, GSK575594A significantly increased the contraction induced by ACh in Ascaris suum (Emax increased from 1.19 g to 1.51 g). GSK575594A may be used in research within the field of antiparasitic studies.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 909418-68-4
- Formel: C24H23F2N3O3S
- Molecular Weight:471.52
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Parasite Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
10 μM
Compound: GSK575594A
|
Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay
Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay
|
[PMID: 26575458] |
Chemical Information
-
CAS. Nr. 909418-68-4
-
Molecular Weight 471.52
-
Formel C24H23F2N3O3S
-
SMILES
O=C(N1CCN(C2=CC=C(N)C=C2F)CC1)C3=CC(S(=O)(C)=O)=CC=C3C4=CC=C(F)C=C4
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
GSK575594A Related Classifications
HY-111161 Related Classifications
Powered by Bioz