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Art. -Nr.: HY-153495

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Prexigebersen

(Synonyms: BP1001)

Prexigebersen (BP1001) is an antisense oligonucleotide targeting Bcl-2 and Grb2. Prexigebersen exhibits antileukemic activity in cell models. Prexigebersen induces apoptosis (apoptosis), cell cycle arrest and ROS production in leukemia cells. Prexigebersen inhibits Grb2 expression, thereby suppressing tumor growth and survival. Prexigebersen can be used in studies related to acute myeloid leukemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 202484-91-1
Molecular Weight:5520.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Prexigebersen Chemical Structure

CAS. Nr.: 202484-91-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

In Vitro

Prexigebersen (3-20 μM; 24 h) induces apoptosis, G0/G1 phase cell cycle arrest, ROS production, mitochondrial membrane depolarization, and growth inhibition in Kasumi-1, Molm-13, MV-4-11 leukemia cell lines and primary AML cells, with an IC₅₀ of 8.479 μM for growth inhibition, and decreases GRB2 and ERK expression in leukemia cell lines^[1].
Prexigebersen enhances the inhibitory effects of Decitabine, or Decitabine plus venetoclax, against AML cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

Kasumi-1, Molm-13, MV-4-11 leukemia cell lines
Concentration:

3 μM
Incubation Time:

24 h
Result:

Induced apoptosis

Chemical Information

CAS. Nr. 202484-91-1
Molecular Weight 5520.57
SMILES

[Prexigebersen]
Synonyms

BP1001
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2242 KB)

Verweise

[1]. Yuan KN, et al. A Photoelectrocatalytic Platform for Sequence-Unrestricted Modification of Oligonucleotide Backbones. Angew Chem Int Ed Engl. 2026;65(6):e24814. [Content Brief]

[2]. Maro Ohanian, et al. Safety and Efficacy of Lower Intensity Induction Therapy with Intravenous Prexigebersen (BP1001) in Patients
with High-Risk and Relapsed/Refractory Acute Myeloid Leukemia (AML). Volume 138, Supplement 1, 23 November 2021, Page 1281.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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- In Vitro
Chemical Information
Reinheit & Dokumentation
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Prexigebersen

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Prexigebersen Related Classifications

HY-153495 Related Classifications