110 Results for "

Ca2 influx

" in MedChemExpress (MCE) Product Catalog:
Products (110)

110 Results for "Ca2 influx" in MCE Product Catalog:

102
Yoda 1
Yoda 1
0 Images
102 Publications Verification
Art. -Nr.: HY-18723
CAS. Nr.: 448947-81-7
Target:  

Piezo Channel Akt ERK Potassium Channel

Forschungsgebiete:  

Cardiovascular Disease

Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation .
38
GSK1016790A
GSK1016790A
0 Images
38 Cited Publications
Art. -Nr.: HY-19608
CAS. Nr.: 942206-85-1
Target:  

TRP Channel Calcium Channel

Forschungsgebiete:  

Cardiovascular Disease Metabolic Disease

GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca 2+ influx and elevate intracellular Ca 2+ in HEK cells .
14
Gabapentin
Gabapentin
0 Images
14 Cited Publications
Art. -Nr.: HY-A0057
CAS. Nr.: 60142-96-3
Target:  

Calcium Channel

Forschungsgebiete:  

Neurological Disease Cancer

Gabapentin is a potent, orally active P/Q type Ca 2+ channel blocker. Gabapentin inhibits neuronal Ca 2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain .
14
Gabapentin hydrochloride
Gabapentin hydrochloride
0 Images
14 Cited Publications
Art. -Nr.: HY-A0057A
CAS. Nr.: 60142-95-2
Target:  

Calcium Channel

Forschungsgebiete:  

Neurological Disease Cancer

Gabapentin hydrochloride is a potent, orally active P/Q type Ca 2+ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca 2+ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain .
13
GSK205
GSK205
0 Images
13 Cited Publications
Art. -Nr.: HY-120691A
CAS. Nr.: 1263068-83-2
Reinheit:  99.47%
Target:  

TRP Channel

Forschungsgebiete:  

Metabolic Disease Inflammation/Immunology

GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19  μM for inhibiting TRPV4-mediated Ca 2+ influx .
11
ISX-9
ISX-9
0 Images
11 Cited Publications
Art. -Nr.: HY-12323
CAS. Nr.: 832115-62-5
Reinheit:  99.19%
Synonyms: Isoxazole 9
Target:  

Calcium Channel

Forschungsgebiete:  

Neurological Disease

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca 2+ influx through both voltage-gated Ca 2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) .
10
Diltiazem hydrochloride
Diltiazem hydrochloride
0 Images
10 Cited Publications
Art. -Nr.: HY-14656
CAS. Nr.: 33286-22-5
Reinheit:  99.47%
Synonyms: CRD-401
Target:  

Calcium Channel

Forschungsgebiete:  

Cardiovascular Disease Cancer

Diltiazem hydrochloride is a Ca 2+ influx inhibitor (slow channel blocker or calcium antagonist).
9
Pyr3
Pyr3
0 Images
9 Cited Publications
Art. -Nr.: HY-108465
CAS. Nr.: 1160514-60-2
Reinheit:  99.90%
Target:  

TRP Channel

Forschungsgebiete:  

Others

Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC50 of 700 nM for TRPC3-mediated Ca 2+ influx.
8
Bay K 8644
Bay K 8644
0 Images
8 Cited Publications
Art. -Nr.: HY-10588
CAS. Nr.: 71145-03-4
Reinheit:  99.96%
Synonyms: (±)-Bay K 8644
Target:  

Calcium Channel

Forschungsgebiete:  

Cardiovascular Disease Neurological Disease

Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644 . Bay K 8644 is a L-type Ca 2+ channel agonist with an EC50 of 17.3 nM. Bay K 8644 increases Ca 2+ influx through sarcolemmal Ca 2+ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects .
5
Urolithin C
Urolithin C
0 Images
5 Cited Publications
Art. -Nr.: HY-135897
CAS. Nr.: 165393-06-6
Reinheit:  ≥98.0%
Category:  

Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields

Target:  

Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca 2+ channel opener and enhances Ca 2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .
3
Bromoenol lactone
Bromoenol lactone
0 Images
3 Cited Publications
Art. -Nr.: HY-107411
CAS. Nr.: 88070-98-8
Reinheit:  99.59%
Synonyms: (6E)-Bromoenol lactone
Target:  

Phospholipase

Forschungsgebiete:  

Inflammation/Immunology

Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca 2+ influx .
3
Pyr10
Pyr10
0 Images
3 Cited Publications
Art. -Nr.: HY-19408
CAS. Nr.: 1315323-00-2
Target:  

TRP Channel

Forschungsgebiete:  

Others

Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca 2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca 2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels .
3
CALP1
CALP1
0 Images
3 Cited Publications
Art. -Nr.: HY-P1077
CAS. Nr.: 145224-99-3
Target:  

mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin

Forschungsgebiete:  

Inflammation/Immunology

CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca 2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity .
3
CALP1 TFA
CALP1 TFA
0 Images
3 Cited Publications
Art. -Nr.: HY-P1077A
Target:  

mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin

Forschungsgebiete:  

Inflammation/Immunology

CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca 2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity .
2
Mesaconitine
Mesaconitine
0 Images
2 Cited Publications
Art. -Nr.: HY-N0724
CAS. Nr.: 2752-64-9
Category:  

Alkaloids Ranunculaceae Other Diseases  Aconitum carmichaeli Debx. Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

NO Synthase

Mesaconitine is a nitric oxide synthase activator. Mesaconitine drives extracellular Na + and Ca 2+ influx into endothelial cells, increases intracellular Na + and Ca 2+ concentrations, and triggers nitric oxide release. Mesaconitine is applicable for pain-related research .
2
Palmitoylcarnitine chloride
Palmitoylcarnitine chloride
0 Images
2 Cited Publications
Art. -Nr.: HY-101017
CAS. Nr.: 6865-14-1
Reinheit:  ≥98.0%
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

Endogenous Metabolite Akt Calcium Channel

Palmitoylcarnitine chloride is a fatty acid-derived mitochondrial substrate, and selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca 2+ influx, and DHT-like effects .
2
Procyanidin A1
Procyanidin A1
0 Images
2 Cited Publications
Art. -Nr.: HY-N2344
CAS. Nr.: 103883-03-0
Synonyms: Proanthocyanidin A1
Category:  

other families Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Biflavones

Target:  

PKC

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca 2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .
2
CGP52411
CGP52411
0 Images
2 Cited Publications
Art. -Nr.: HY-103442
CAS. Nr.: 145915-58-8
Reinheit:  99.55%
Synonyms: DAPH
Target:  

EGFR Amyloid-β

Forschungsgebiete:  

Neurological Disease Cancer

CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitive EGFR inhibitor with an IC50 of 0.3 μM. CGP52411 blocks the toxic influx of Ca 2+ ions into neuronal cells, and dramatic inhibits and reverses the formation of β-amyloid (Aβ42) fibril aggregates associated with Alzheimer's disease .
1
Englerin A
Englerin A
0 Images
1 Cited Publications
Art. -Nr.: HY-133168
CAS. Nr.: 1094250-15-3
Reinheit:  99.43%
Category:  

other families Terpenoids Sesquiterpenes Plants Disease Research Fields Cancer

Target:  

TRP Channel

Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca 2+ influx and Ca 2+ cell overload .
1
ω-Agatoxin IVA
ω-Agatoxin IVA
0 Images
1 Cited Publications
Art. -Nr.: HY-P1080
CAS. Nr.: 145017-83-0
Target:  

Calcium Channel

Forschungsgebiete:  

Cardiovascular Disease Neurological Disease

ω-Agatoxin IVA is a potent, selective P/Q type Ca 2+ (Cav2.1) channel blocker with IC50 values of 2 nM and 90 nM. ω-Agatoxin IVA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA can be used for the research of neurological and cardiovascular disease .
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