1263068-83-2
1263068-83-2
Chemical Structure
GSK205
- CAS No.: 1263068-83-2
- Formula:C24H25BrN4S
- Molecular Weight:481.45
IUPAC Name: N-(4-(2-(benzyl(methyl)amino)ethyl)phenyl)-5-(pyridin-3-yl)thiazol-2-amine hydrobromide
InChIKey: LQGOJHGNGSOUKL-UHFFFAOYSA-N
SMILES: CN(CCC1=CC=C(NC2=NC=C(C3=CC=CN=C3)S2)C=C1)CC4=CC=CC=C4.[H]Br
Biological Activity: GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19 μM for inhibiting TRPV4-mediated Ca2+ influx[1][2].
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GSK205 | 99.47% | GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19 μM for inhibiting TRPV4-mediated Ca2+ influx. | ||||||||||||||||||||
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References
- [1]. Ye L, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28;151(1):96-110. [Content Brief]
- [2]. Kanju P, et al. Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Sci Rep. 2016 Jun 1;6:26894. [Content Brief]
