CGP 53716

Cat. No.: HY-101837: FAQs
Data Sheet Handling Instructions

Molarity Calculator

CGP 53716 is a potent protein tyrosine kinase inhibitor. CGP 53716 has selective activity of platelet-derived growth factor (PDGF) receptor. CGP 53716 can be used in the study of disease induced by abnormal cell proliferation induced by PDGF receptor activation .

For research use only. We do not sell to patients.

CGP 53716 Chemical Structure

CAS No. : 152459-94-4

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

381.43

Formula

C₂₃H₁₉N₅O

CAS No.

152459-94-4

SMILES

O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (327.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6217 mL	13.1086 mL	26.2171 mL
5 mM	0.5243 mL	2.6217 mL	5.2434 mL
10 mM	0.2622 mL	1.3109 mL	2.6217 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Buchdunger E, et al. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2558-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6217 mL	13.1086 mL	26.2171 mL	65.5428 mL
	5 mM	0.5243 mL	2.6217 mL	5.2434 mL	13.1086 mL
	10 mM	0.2622 mL	1.3109 mL	2.6217 mL	6.5543 mL
	15 mM	0.1748 mL	0.8739 mL	1.7478 mL	4.3695 mL
	20 mM	0.1311 mL	0.6554 mL	1.3109 mL	3.2771 mL
	25 mM	0.1049 mL	0.5243 mL	1.0487 mL	2.6217 mL
	30 mM	0.0874 mL	0.4370 mL	0.8739 mL	2.1848 mL
	40 mM	0.0655 mL	0.3277 mL	0.6554 mL	1.6386 mL
	50 mM	0.0524 mL	0.2622 mL	0.5243 mL	1.3109 mL
	60 mM	0.0437 mL	0.2185 mL	0.4370 mL	1.0924 mL
	80 mM	0.0328 mL	0.1639 mL	0.3277 mL	0.8193 mL
	100 mM	0.0262 mL	0.1311 mL	0.2622 mL	0.6554 mL

CGP 53716 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP 53716152459-94-4CGP53716CGP-53716Othersprotein-tyrosine kinase inhibitorplatelet-derived growth factorInhibitorinhibitorinhibit

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