Art. -Nr.: HY-12323

ISX-9

(Synonyms: Isoxazole 9)

11 Cited Publications

Kundenbewertung

Based on 11 publication(s) in Google Scholar

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca²⁺ influx through both voltage-gated Ca²⁺ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs).

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Reinheit: 99.76%
CAS. Nr.: 832115-62-5
Formel: C₁₁H₁₀N₂O₂S
Molecular Weight:234.27

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

ISX-9 Chemical Structure

CAS. Nr.: 832115-62-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (11)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

In Vivo

ISX-9 (20 mg/kg; for 12 days; mice) treatment improves hippocampal function. ISX-9 enhances spatial memory ability in the Morris water maze test. ISX-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 832115-62-5
Appearance Solid
Molecular Weight 234.27
Formel C₁₁H₁₀N₂O₂S
Color Off-white to yellow
SMILES

O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3
Synonyms

Isoxazole 9
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (11)

All RT-PCRWBCell Imaging/StainingHistological Imaging/Staining

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Journal Impact Factor

Adv Sci (Weinh)

Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons. [Abstract]

2022 May;9(13):e2104682. PMID: 35240008

ISX-9 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 May;9(13):e2104682. [Abstract]

After treatment with Ble and ISX-9 (20–50 µM) for 22 days, neuron-like HFF cells expressed SYT1 and PSD95.
Mater Today Chem

aterials Today Chemistry 12 (2019) 78e84
Cells

Neuronal Differentiation of GBM-Initiating Cells Combined with Elimination of Undifferentiated Cells Preserves Motor Function. [Abstract]

2026 Mar 18;15(6):539. PMID: 41892329
Stem Cell Reports

Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules. [Abstract]

2017 Mar 14;8(3):538-547. PMID: 28216149
Stem Cells Transl Med

ISX-9 Promotes KGF Secretion From MSCs to Alleviate ALI Through NGFR-ERK-TAU-β-Catenin Signaling Axis. [Abstract]

2024 Mar 15;13(3):255-267. PMID: 38159248

ISX-9 purchased from MedChemExpress. Usage Cited in: Stem Cells Transl Med. 2024 Mar 15;13(3):255-267. [Abstract]

RT-qPCR was performed to detect the changes in KGF mRNA levels in BMSCs after the action time of ISX-9 at concentrations of 0,1.25, 2.5, and 5 μM for 12, 24, 48, and72 hours, respectively.

ISX-9 purchased from MedChemExpress. Usage Cited in: Stem Cells Transl Med. 2024 Mar 15;13(3):255-267. [Abstract]

Western blot verified that ISX-9 acted on BMSCs and upregulated NGFR and its downstream proteins.

ISX-9 purchased from MedChemExpress. Usage Cited in: Stem Cells Transl Med. 2024 Mar 15;13(3):255-267. [Abstract]

Western blot was used to detect the effect of the ERK inhibitor U0126 (U0126/10 μM) on changes in downstream NGFR proteins induced by ISX-9 (2.5 μM).

ISX-9 purchased from MedChemExpress. Usage Cited in: Stem Cells Transl Med. 2024 Mar 15;13(3):255-267. [Abstract]

H&E staining was used to assess lung histopathological changes. The image shows that LPS induces lung histopathological changes, while administration of BMSCs and ISX-9 (25 mg/kg, intraperitoneal injection) reduces lung injury.
Int J Mol Sci

The Efficiency of Neurospheres Derived from Human Wharton's Jelly Mesenchymal Stem Cells for Spinal Cord Injury Regeneration in Rats. [Abstract]

2023 Feb 14;24(4):3846. PMID: 36835256
ACS Chem Neurosci

Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules. [Abstract]

2018 Dec 19;9(12):3175-3185. PMID: 30091580
bioRxiv

2025 Aug 07.
bioRxiv

2024 November 15.
Brain Science Advances

2022 Feb.
Patent

US20180273906A1.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (426.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.2686 mL

21.3429 mL

42.6858 mL

5 mM

0.8537 mL

4.2686 mL

8.5372 mL

10 mM

0.4269 mL

2.1343 mL

4.2686 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (10.67 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Petrik D, et al. Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. FASEB J. 2012 Aug;26(8):3148-3162. [Content Brief]

[2]. Jay W Schneider, et al. Small-molecule activation of neuronal cell fate. Nat Chem Biol. 2008 Jul;4(7):408-10. [Content Brief]

[3]. Jamie L Russell, et al. Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem Biol. 2012 Jun 15;7(6):1067-76. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.2686 mL	21.3429 mL	42.6858 mL	106.7145 mL
	5 mM	0.8537 mL	4.2686 mL	8.5372 mL	21.3429 mL
	10 mM	0.4269 mL	2.1343 mL	4.2686 mL	10.6714 mL
	15 mM	0.2846 mL	1.4229 mL	2.8457 mL	7.1143 mL
	20 mM	0.2134 mL	1.0671 mL	2.1343 mL	5.3357 mL
	25 mM	0.1707 mL	0.8537 mL	1.7074 mL	4.2686 mL
	30 mM	0.1423 mL	0.7114 mL	1.4229 mL	3.5571 mL
	40 mM	0.1067 mL	0.5336 mL	1.0671 mL	2.6679 mL
	50 mM	0.0854 mL	0.4269 mL	0.8537 mL	2.1343 mL
	60 mM	0.0711 mL	0.3557 mL	0.7114 mL	1.7786 mL
	80 mM	0.0534 mL	0.2668 mL	0.5336 mL	1.3339 mL
	100 mM	0.0427 mL	0.2134 mL	0.4269 mL	1.0671 mL

Keywords

ISX-9

11 Cited Publications

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ISX-9

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Reprogramming Compound Library

Mechanoreceptors Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) ISX-9

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (11)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

ISX-9

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Reprogramming Compound Library

Mechanoreceptors Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) ISX-9

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (11)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

ISX-9 Related Classifications

Art. -Nr.: HY-12323