145017-83-0
Chemical Structure
ω-Agatoxin IVA
- CAS No.: 145017-83-0
- Formula:C217H360N68O60S10
- Molecular Weight:5202.25
SMILES: O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(NC1)=O)=O)=O)=O)NC2=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CCC(O)=O)=O)NC5=O)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCSC)C(NCC(N[C@@H]([C@H](O)C)C(N[C@H]5CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(NCC(NCC(N[C@@H]([C@H](O)C)C(N8[C@@H](CCC8)C(N[C@H]2CSSC[C@@H](C(N[C@@H](CCCCN)C(N9[C@@H](CCC9)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC4=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50 values of 2 nM and 90 nM. ω-Agatoxin IVA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA can be used for the research of neurological and cardiovascular disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ω-Agatoxin IVA | 98.71% | ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50 values of 2 nM and 90 nM. ω-Agatoxin IVA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA can be used for the research of neurological and cardiovascular disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Teramoto T, et al. A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons. Brain Res. 1997;756(1-2):225-230. [Content Brief]
- [2]. Lundy P M, Frew R. Effect of ω-agatoxin-IVA on autonomic neurotransmission[J]. European journal of pharmacology, 1994, 261(1-2): 79-84. [Content Brief]
- [3]. Hong KW, et al. Effect of omega-conotoxin GVIA and omega-agatoxin IVA on the capsaicin-sensitive calcitonin gene-related peptide release and autoregulatory vasodilation in rat pial arteries. J Cereb Blood Flow Metab. 1999;19(1):53-60. [Content Brief]
Keywords
