Art. -Nr.: HY-N2344

Procyanidin A1

(Synonyms: Proanthocyanidin A1)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.

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Reinheit: 99.34%
CAS. Nr.: 103883-03-0
Formel: C₃₀H₂₄O₁₂
Molecular Weight:576.50

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Procyanidin A1 Chemical Structure

CAS. Nr.: 103883-03-0

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Alle PKC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	>70 μM Compound: 5	Cytotoxicity against human Jurkat cells after 24 to 72 hrs by MTT assay Cytotoxicity against human Jurkat cells after 24 to 72 hrs by MTT assay	[PMID: 23268742]
MCF7	IC₅₀	>70 μM Compound: 5	Cytotoxicity against human MCF7 cells after 24 to 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 to 72 hrs by MTT assay	[PMID: 23268742]
MT4	CC₅₀	144.3 μg/mL Compound: 8, proanthocyanidin A1	Cytotoxicity against human MT4 cells by MTT assay Cytotoxicity against human MT4 cells by MTT assay	[PMID: 10425115]
MT4	IC₅₀	14 μg/mL Compound: 8, proanthocyanidin A1	Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 10425115]
PBMC	IC₅₀	25 μM Compound: 3	Immunomodulatory activity in PHA-stimulated human PBMC assessed as inhibition of IL2 production after 3 days by enzyme immuno assay Immunomodulatory activity in PHA-stimulated human PBMC assessed as inhibition of IL2 production after 3 days by enzyme immuno assay	[PMID: 11975489]
PBMC	IC₅₀	30.6 μM Compound: 3	Inhibition of PHA-stimulated human PBMC proliferation assessed as [3H]thymidine uptake after 3 days by scintillation counting Inhibition of PHA-stimulated human PBMC proliferation assessed as [3H]thymidine uptake after 3 days by scintillation counting	[PMID: 11975489]
PBMC	IC₅₀	5.1 μM Compound: 3	Immunomodulatory activity in PHA-stimulated human PBMC assessed as inhibition of IFN-gamma production after 3 days by enzyme immuno assay Immunomodulatory activity in PHA-stimulated human PBMC assessed as inhibition of IFN-gamma production after 3 days by enzyme immuno assay	[PMID: 11975489]

In Vivo

Procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 103883-03-0
Appearance Solid
Molecular Weight 576.50
Formel C₃₀H₂₄O₁₂
Color White to off-white
SMILES

O[C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C4C(O[C@]5(C6=CC=C(O)C(O)=C6)OC7=CC(O)=CC(O)=C7[C@@]4([H])[C@H]5O)=CC(O)=C3C1
Synonyms

Proanthocyanidin A1
Structure Classification
- Flavonoids
- Biflavones
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Curr Top Nutraceutical Res

2022 May 4.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (173.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7346 mL

8.6730 mL

17.3461 mL

5 mM

0.3469 mL

1.7346 mL

3.4692 mL

10 mM

0.1735 mL

0.8673 mL

1.7346 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (4.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tomochika K, et al. Effects of peanut-skin procyanidin A1 on degranulation of RBL-2H3 cells. Biosci Biotechnol Biochem. 2011;75(9):1644-8. [Content Brief]

[2]. Takano F, et al. Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. Biol Pharm Bull. 2007 May;30(5):922-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7346 mL	8.6730 mL	17.3461 mL	43.3651 mL
	5 mM	0.3469 mL	1.7346 mL	3.4692 mL	8.6730 mL
	10 mM	0.1735 mL	0.8673 mL	1.7346 mL	4.3365 mL
	15 mM	0.1156 mL	0.5782 mL	1.1564 mL	2.8910 mL
	20 mM	0.0867 mL	0.4337 mL	0.8673 mL	2.1683 mL
	25 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.7346 mL
	30 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4455 mL
	40 mM	0.0434 mL	0.2168 mL	0.4337 mL	1.0841 mL
	50 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.8673 mL
	60 mM	0.0289 mL	0.1446 mL	0.2891 mL	0.7228 mL
	80 mM	0.0217 mL	0.1084 mL	0.2168 mL	0.5421 mL
	100 mM	0.0173 mL	0.0867 mL	0.1735 mL	0.4337 mL

Keywords

Procyanidin A1

2 Cited Publications

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Procyanidin A1

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Publications Citing Use of MedChemExpress (MCE) Procyanidin A1

Alle PKC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Procyanidin A1 Related Classifications

Art. -Nr.: HY-N2344