150 Results for "

Factor H

" in MedChemExpress (MCE) Product Catalog:
Products (150)

150 Results for "Factor H" in MCE Product Catalog:

  • Recombinant Proteins Recommended:
16
Chloramphenicol
Chloramphenicol
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16 Publications Verification
Cat. No.: HY-B0239
CAS No.: 56-75-7
Category:  

Anti-aging Disease Research Antibacterial Endogenous metabolite Other Antibiotics Infection Human Gut Microbiota Metabolites Microorganisms Plant Cell Culture Antibiotics Resistance Selection Animal Husbandry Anticancer Disease Research Fields Cancer

Target:  

Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP

Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .
12
L-Cysteine hydrochloride
L-Cysteine hydrochloride
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12 Cited Publications
Cat. No.: HY-Y0337A
CAS No.: 52-89-1
Category:  

Anti-aging Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .
7
Doxepin Hydrochloride
Doxepin Hydrochloride
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7 Cited Publications
Cat. No.: HY-B0725
CAS No.: 1229-29-4
Target:  

Histamine Receptor Cytochrome P450

Research Areas:  

Neurological Disease Cancer

Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2 . Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant .
. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system .
. Doxepin has also been proposed as a protective factor against oxidative stress .
.
5
8-Gingerol
8-Gingerol
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5 Cited Publications
Cat. No.: HY-N0447
CAS No.: 23513-08-8
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Disease Research Fields Inflammation/Immunology Cancer Zingiberaceae

Target:  

TRP Channel Bacterial Apoptosis Autophagy STAT PERK EGFR PI3K Akt mTOR Caspase MMP

8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.
2
Phospho-PERK (Thr980) Antibody
Phospho-PERK (Thr980) Antibody
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2 Cited Publications
Cat. No.: HY-P81190
Synonyms: p-PERK(Thr980); PERK(Phospho Thr980); PERK(Phospho T980); mo(Thr980)/hu (Thr982)/rat (Thr974); HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS; DKFZp781H1925; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation Factor 2 alpha kinase 3; Heme regulated EIF2 alpha kinase.

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, ICC/IF, FC

Reactivity:  

Human, Mouse, Rat

1
(E)-Ferulic acid
(E)-Ferulic acid
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1 Cited Publications
Cat. No.: HY-N0060B
CAS No.: 537-98-4
Synonyms: (E)-Coniferic acid
Category:  

Plants Endogenous metabolite Human Gut Microbiota Metabolites other families Microorganisms Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Disease Research Fields Cancer

Target:  

β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite

(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.
1
Bepotastine besilate
Bepotastine besilate
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1 Cited Publications
Cat. No.: HY-A0015
CAS No.: 190786-44-8
Target:  

Histamine Receptor

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology

Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .
1
Bepotastine
Bepotastine
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1 Cited Publications
Cat. No.: HY-I0021
CAS No.: 125602-71-3
Target:  

Histamine Receptor

Research Areas:  

Inflammation/Immunology Endocrinology

Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .
1
Anti-Mouse IFN gamma Antibody (H22)
Anti-Mouse IFN gamma Antibody (H22)
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1 Cited Publications
Cat. No.: HY-P99136

Target:  

IFNAR

Research Areas:  

Infection Inflammation/Immunology

Anti-Mouse IFN gamma Antibody (H22) is an anti-mouse IFN gamma IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IFN gamma Antibody (H22) abrogates specific binding of I25II-rIFN-γ to macrophages. Anti-Mouse IFN gamma Antibody (H22) inhibits macrophage-activating factor (MAF) (ID50 = 56 ng). Anti-Mouse IFN gamma Antibody (H22) inhibits IFN-gamma dependent antiviral activity (ID50 = 2 ng). Anti-Mouse IFN gamma Antibody (H22) neutralizes IFNγ in mice. Anti-Mouse IFN gamma Antibody (H22) can be used for the researches of inflammation and infection, such as arthritis .
1
NLS-StAx-h TFA
NLS-StAx-h TFA
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1 Cited Publications
Cat. No.: HY-P2272A
Target:  

Wnt β-catenin

Research Areas:  

Cancer

NLS-StAx-h TFA is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells .
1
Complement Factor B/CFB Protein, Mouse (His)
Complement Factor B/CFB Protein, Mouse (His)
0 Images
1 Cited Publications
Cat. No.: HY-P72137
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cfb; Bf; H2-BfComplement Factor B; EC 3.4.21.47; C3/C5 convertase; Complement Factor B Ba fragment; Complement Factor B Bb fragment
Species:  
Mouse
Source:  
E. coli
1
7,8-Dimethoxycoumarin
7,8-Dimethoxycoumarin
0 Images
1 Cited Publications
Cat. No.: HY-N4280
CAS No.: 2445-80-9
Category:  

Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Citrus reticulata Blanco

Target:  

Na+/K+ ATPase Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related

7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H +/K +-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis .
1
NME1/NDPKA Protein, Human (His)
NME1/NDPKA Protein, Human (His)
0 Images
1 Cited Publications
Cat. No.: HY-P70299
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: rHuNucleoside diphosphate kinase A/NDPKA, His; Nucleoside Diphosphate Kinase A; NDK A; NDP Kinase A; Granzyme A-Activated DNase; GAAD; Metastasis Inhibition Factor nm23; Tumor Metastatic Process-Associated Protein; nm23-H1; NME1; NDPKA; NM23
Species:  
Human
Source:  
E. coli
Cobra Venom Factor
Cobra Venom Factor
0 Images
Cat. No.: HY-NP004
Synonyms: CVF
Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .
Tenatoprazole
Tenatoprazole
0 Images
Cat. No.: HY-17421
CAS No.: 113712-98-4
Synonyms: TU-199
Target:  

Proton Pump

Research Areas:  

Infection Inflammation/Immunology

Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H +/K +-ATPase activity with an IC50 of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV .
Barnidipine hydrochloride
Barnidipine hydrochloride
0 Images
Cat. No.: HY-107322
CAS No.: 104757-53-1
Purity:  99.96%
Synonyms: Mepirodipine hydrochloride; YM-09730-5
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease

Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [ 3H] initrendipine binding sites (Ki = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance .
Oglufanide
Oglufanide
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Cat. No.: HY-13718
CAS No.: 38101-59-6
Purity:  98.97%
Synonyms: H-Glu-Trp-OH; L-Glutamyl-L-tryptophan
Category:  

Cardiovascular Disease Animals Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

VEGFR HCV Endogenous Metabolite

Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .
Ganoderic acid H
Ganoderic acid H
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Cat. No.: HY-N1513
CAS No.: 98665-19-1
Category:  

Triterpenes Microorganisms Terpenoids Polyporaceae Plants Disease Research Fields Cancer

Target:  

AP-1 NF-κB

Ganoderic acid H is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderic acid H suppresses growth and invasive behavior of breast cancer cells through the inhibition of transcription factors AP-1 and NF-kappaB signaling .
IMM-H007
IMM-H007
0 Images
Cat. No.: HY-141645
CAS No.: 1221412-23-2
Purity:  97.07%
Synonyms: WS070117
Target:  

AMPK TGF-β Receptor NF-κB JNK AP-1

Research Areas:  

Cardiovascular Disease Metabolic Disease Inflammation/Immunology

IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis .
Chloramphenicol (Standard)
Chloramphenicol (Standard)
0 Images
Cat. No.: HY-B0239R
CAS No.: 56-75-7
Category:  

Disease Research Antibacterial Endogenous metabolite Other Antibiotics Human Gut Microbiota Metabolites Microorganisms Plant Cell Culture Antibiotics Resistance Selection Animal Husbandry Anticancer

Target:  

Reference Standards Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP

Chloramphenicol (Standard) is the analytical standard of Chloramphenicol. This product is intended for research and analytical applications. Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .
Assay Types