125602-71-3
125602-71-3
Chemical Structure
Bepotastine
- CAS No.: 125602-71-3
- Formula:C21H25ClN2O3
- Molecular Weight:388.89
IUPAC Name: (S)-4-(4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic acid
InChIKey: YWGDOWXRIALTES-NRFANRHFSA-N
SMILES: O=C(O)CCCN1CCC(O[C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=N3)CC1
Biological Activity: Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Bepotastine | 99.88% | Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Bepotastine (Standard) | ≥98% | Bepotastine (Standard) is the analytical standard of Bepotastine. This product is intended for research and analytical applications. Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.79
HY-A0015Bepotastine besilate -
Similarity Score 0.79
HY-A0015A(Rac)-Bepotastine besilate -
Similarity Score 0.78
HY-I0021ABepotastine tosylate -
Similarity Score 0.74
HY-322422-{s-(4-Chlorophenyl)(4-Piperidinyloxy)Methyl}Pyridine -
Similarity Score 0.63
HY-B1589ARCarbinoxamine maleate salt (Standard) -
Similarity Score 0.62
HY-B1589(±)-Carbinoxamine -
Similarity Score 0.59
HY-B1589ASCarbinoxamine-d6 maleate -
Similarity Score 0.58
HY-B1589S(±)-Carbinoxamine-d6 -
Similarity Score 0.57
HY-108259RHQL-79 (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Kida T, et al. Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul;91(1):85-91. [Content Brief]
- [2]. Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811(18)30186-5. [Content Brief]
- [3]. Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008;145(4):277-82. [Content Brief]
- [4]. Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct;26(10):2329-38. [Content Brief]
