1. GPCR/G Protein
    Apoptosis
  2. Ras
    Apoptosis
  3. AZA1

AZA1 (Synonyms: Rac1/Cdc42-IN-1)

Cat. No.: HY-136383 Purity: 98.65%
Handling Instructions

AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.

For research use only. We do not sell to patients.

AZA1 Chemical Structure

AZA1 Chemical Structure

CAS No. : 1071098-42-4

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5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
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100 mg USD 1950 In-stock
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Description

AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion[1][2].

In Vitro

AZA1 (Rac1/Cdc42-IN-1) (2-10 μM; 72 hours) blocks the proliferation of human prostate cancer cells 22Rv1 prostate cancer cells[1].
AZA1 (2-10 μM; 24 hours) reduces phosphorylation of PAK1, AKT and BAD in EGF-stimulated 22Rv1 prostate cancer cells[1].
AZA1 (10 μM; 24 hours) blocks Rac1 and Cdc42-dependent cell cycle events in 22Rv1 prostate cancer cells[1].
AZA1 blocks Rac1 and Cdc42-dependent migration of 22Rv1, DU 145 and PC-3 prostate cancer cells[1].
AZA1 affects cell motility and actin rearrangement in prostate cancer cells by suppressing Rac1 and Cdc42 activity via PAK1/2 phosphorylation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: 22Rv1 prostate cancer cells
Concentration: 2, 5, 10 μM
Incubation Time: 72 hours
Result: Suppressed 22Rv1 prostate cancer cell proliferation in both unstimulated and EGF-stimulated cancer cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: 22Rv1 prostate cancer cells (EGF-stimulated)
Concentration: 2, 5, 10 μM
Incubation Time: 24 hours
Result: Reduced phosphorylation of PAK1, AKT and BAD in EGF-stimulated 22Rv1 prostate cancer cells.
In Vivo

AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) is potent in suppressing human 22Rv1 xenograft growth in mice and improving survival[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5 week-old athymic nu/nu (nude) mice (bearing 22Rv1 prostate cancer cell xenografts)[1]
Dosage: 100 μg in 100 µl 30% DMSO
Administration: I.p.; daily for 2 weeks
Result: The suppressive effect of AZA1 on tumor growth was significant.
Molecular Weight

368.43

Formula

C₂₂H₂₀N₆

CAS No.

1071098-42-4

SMILES

CC(N1)=CC2=C1C=CC(NC3=NC(NC4=CC5=C(NC(C)=C5)C=C4)=NC=C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

AZA1Rac1/Cdc42-IN-1AZA 1AZA-1RasApoptosisprostatecancergrowthmigrationinvasionproliferationphosphorylationInhibitorinhibitorinhibit

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AZA1
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