Art. -Nr.: HY-19314A

Azvudine hydrochloride

Name: Azvudine hydrochloride
Brand: MedChemExpress
SKU: HY-19314A
Price: 170.00 USD
Availability: InStock
Rating: 5 (6 reviews)

(Synonyms: RO-0622 hydrochloride; FNC hydrochloride)

6 Cited Publications

Kundenbewertung

Based on 6 publication(s) in Google Scholar

Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains. Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Reinheit : 99.19%
CAS. Nr.: 1333126-31-0
Formel: C₉H₁₂ClFN₆O₄
Molecular Weight:322.68

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Azvudine hydrochloride Chemical Structure

CAS. Nr.: 1333126-31-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
Publications (6)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains^[1]. Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

^[1]

HIV-1

0.03-6.92 nM (EC₅₀)

HIV-2

0.018-0.02 nM (EC₅₀)

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Cellular Effect

Cell Line	Type	Value	Description	References
ACH-2 cell line	IC₅₀	0.11 μM Compound: 11	Cytotoxicity activity against human ACH2 by CellTiter-Glo luminescent cell viability assay Cytotoxicity activity against human ACH2 by CellTiter-Glo luminescent cell viability assay	[PMID: 21745701]
HEK-293T	IC₅₀	>140 μM Compound: 11	Cytotoxicity activity against human 293T by CellTiter-Glo luminescent cell viability assay Cytotoxicity activity against human 293T by CellTiter-Glo luminescent cell viability assay	[PMID: 21745701]
HepG2	IC₅₀	>140 μM Compound: 11	Cytotoxicity activity against human HepG2 by CellTiter-Glo luminescent cell viability assay Cytotoxicity activity against human HepG2 by CellTiter-Glo luminescent cell viability assay	[PMID: 21745701]
MT2	EC₅₀	0.13 nM Compound: 11	Antiviral activity against vesicular stomatitis virus G-pseudotyped Human immunodeficiency virus 1 NL4-3 infected in human MT2 cells assessed as inhibition of viral replication after 48 hrs by luciferase activity reporter gene assay Antiviral activity against vesicular stomatitis virus G-pseudotyped Human immunodeficiency virus 1 NL4-3 infected in human MT2 cells assessed as inhibition of viral replication after 48 hrs by luciferase activity reporter gene assay	[PMID: 21745701]
MT4	IC₅₀	0.12 μM Compound: 11	Cytotoxicity activity against human MT4 by CellTiter-Glo luminescent cell viability assay Cytotoxicity activity against human MT4 by CellTiter-Glo luminescent cell viability assay	[PMID: 21745701]
PBMC	IC₅₀	0.15 μM Compound: 11	Cytotoxicity activity against human PBMC by CellTiter-Glo luminescent cell viability assay Cytotoxicity activity against human PBMC by CellTiter-Glo luminescent cell viability assay	[PMID: 21745701]
TZM	IC₅₀	>140 μM Compound: 11	Cytotoxicity activity against human TZM-bl by CellTiter-Glo luminescent cell viability assay Cytotoxicity activity against human TZM-bl by CellTiter-Glo luminescent cell viability assay	[PMID: 21745701]

In Vitro

Azvudine (RO-0622) hydrochloride displays strong inhibition on wild-type HIV-1_IIIB and HIV-1_RF with an EC₅₀ ranging from 30 to 110 pM. The EC₅₀ values of Azvudine hydrochloride against HIV-1_KM018, HIV-1_TC-1 and HIV-1_{WAN T69N} are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-1_74V, PIs-resistant strains HIV-1_{L10R/M46I/L63P/V82T/I84V} and HIV-1_{RF V82F/184V}, and FIs-resistant strain pNL4-3_{gp41 (36G) V38A/N42T}. The EC₅₀ values of Azvudine hydrochloride against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS. Nr. 1333126-31-0
Appearance Solid
Molecular Weight 322.68
Formel C₉H₁₂ClFN₆O₄
Color Off-white to yellow
SMILES

O[C@@H]1[C@](CO)(N=[N+]=[N-])O[C@@H](N2C(N=C(N)C=C2)=O)[C@H]1F.Cl
Synonyms

RO-0622 hydrochloride; FNC hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (6)

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Signal Transduct Target Ther

Real-world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study. [Abstract]

2025 Jan 17;10(1):30. PMID: 39819859
Acta Pharm Sin B

Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect. [Abstract]

2024 Jul;14(7):3140-3154. PMID: 39027259
Mikrochim Acta

Strain-promoted azide-alkyne cycloaddition-based fluorometric detection of azvudine using DBCO-functionalized carbon dots. [Abstract]

2025 Dec 8;193(1):10. PMID: 41359210
Antiviral Res

Metformin inhibits EV-A71 and CVA16 infections by regulating TRIB3-SCARB2 axis and activating AMPK. [Abstract]

2025 Mar:235:106081. PMID: 39826812
NAR Mol Med

Mechanism and spectrum of inhibition of viral polymerases by 2'-deoxy-2'-β-fluoro-4'-azidocytidine or azvudine. [Abstract]

2025 Aug 11;2(3):ugaf029. PMID: 40900943
Biomed Pharmacother

Azvudine exhibits potent differentiation-inducing effect by targeting the TERT/p21 axis in acute myeloid leukemia. [Abstract]

2025 Jul:188:118215. PMID: 40435838

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 50 mg/mL (154.95 mM; Need ultrasonic)

DMSO : 25 mg/mL (77.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0990 mL

15.4952 mL

30.9905 mL

5 mM

0.6198 mL

3.0990 mL

6.1981 mL

10 mM

0.3099 mL

1.5495 mL

3.0990 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang RR, et al. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21;9(8):e105617. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	3.0990 mL	15.4952 mL	30.9905 mL	77.4761 mL
	5 mM	0.6198 mL	3.0990 mL	6.1981 mL	15.4952 mL
	10 mM	0.3099 mL	1.5495 mL	3.0990 mL	7.7476 mL
	15 mM	0.2066 mL	1.0330 mL	2.0660 mL	5.1651 mL
	20 mM	0.1550 mL	0.7748 mL	1.5495 mL	3.8738 mL
	25 mM	0.1240 mL	0.6198 mL	1.2396 mL	3.0990 mL
	30 mM	0.1033 mL	0.5165 mL	1.0330 mL	2.5825 mL
	40 mM	0.0775 mL	0.3874 mL	0.7748 mL	1.9369 mL
	50 mM	0.0620 mL	0.3099 mL	0.6198 mL	1.5495 mL
	60 mM	0.0517 mL	0.2583 mL	0.5165 mL	1.2913 mL
H₂O	80 mM	0.0387 mL	0.1937 mL	0.3874 mL	0.9685 mL
H₂O	100 mM	0.0310 mL	0.1550 mL	0.3099 mL	0.7748 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Azvudine hydrochloride

6 Cited Publications

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Azvudine hydrochloride

Publications Citing Use of MedChemExpress (MCE) Azvudine hydrochloride

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