Strain-promoted azide-alkyne cycloaddition-based fluorometric detection of azvudine using DBCO-functionalized carbon dots

  • Mikrochim Acta. 2025 Dec 8;193(1):10. doi: 10.1007/s00604-025-07754-1.
Glowi Alasiri  1 ,  Ali M Alaseem  2 ,  Omar A Almohammed  3 ,  Yousef A Bin Jardan  4 ,  Mohamed M El-Wekil  5 ,  Ramadan Ali  6 ,  Jong Pil Park  7 ,  Al-Montaser Bellah H Ali  8
Affiliations
  • 1. Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317, Saudi Arabia. [email protected].
  • 2. Department of Pharmacology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317, Saudi Arabia.
  • 3. Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
  • 4. Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
  • 5. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
  • 6. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia.
  • 7. Department of Food Science and Technology, and GreenTech-based Food Safety Research Group, Chung-Ang University, BK21 Four, Anseong, 17546, Republic of Korea.
  • 8. Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317, Saudi Arabia.
PMID: 41359210 DOI: 10.1007/s00604-025-07754-1
Keywords
Azvudine; Click chemistry; Fluorescence quenching; Strain-promoted azide-alkyne cycloaddition; Therapeutic drug monitoring.
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