1. Anti-infection
  2. Reverse Transcriptase
    HIV
    HBV
    HCV
  3. Azvudine

Azvudine (Synonyms: RO-0622; FNC)

Cat. No.: HY-19314
Handling Instructions

Azvudine is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains.

For research use only. We do not sell to patients.

Azvudine Chemical Structure

Azvudine Chemical Structure

CAS No. : 1011529-10-4

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Description

Azvudine is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains[1].

In Vitro

Azvudine displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T. The EC50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1].

Molecular Weight

286.22

Formula

C₉H₁₁FN₆O₄

CAS No.

1011529-10-4

SMILES

NC(C=CN1[[email protected]@H]2O[[email protected]@](N=[N+]=[N-])([[email protected]]([[email protected]@H]2F)O)CO)=NC1=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AzvudineRO-0622FNCRO0622RO 0622Reverse TranscriptaseHIVHBVHCVHuman immunodeficiency virusHepatitis B virusHepatitis C virusNRTIresistantmutationanalogueInhibitorinhibitorinhibit

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Azvudine
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