2. Anti-infection
  3. Reverse Transcriptase HIV HBV HCV
  4. Azvudine

Azvudine  (Synonyms: RO-0622; FNC)

Cat. No.: HY-19314 Purity: 99.60%
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Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains. Azvudine is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azvudine Chemical Structure

Azvudine Chemical Structure

CAS No. : 1011529-10-4

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5 mg USD 171 In-stock
10 mg USD 280 In-stock
25 mg USD 550 In-stock
50 mg USD 880 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Azvudine:

Azvudine Related Antibodies

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Description

Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains[1]. Azvudine is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target[1]

HIV-1

0.03-6.92 nM (EC50)

HIV-2

0.018-0.02 nM (EC50)

In Vitro

Azvudine (RO-0622) displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T. The EC50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azvudine Related Antibodies
Clinical Trial
Molecular Weight

286.22

Formula

C9H11FN6O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@](CO)(N=[N+]=[N-])O[C@@H](N2C(N=C(N)C=C2)=O)[C@H]1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (436.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4938 mL 17.4691 mL 34.9382 mL
5 mM 0.6988 mL 3.4938 mL 6.9876 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4938 mL 17.4691 mL 34.9382 mL 87.3454 mL
5 mM 0.6988 mL 3.4938 mL 6.9876 mL 17.4691 mL
10 mM 0.3494 mL 1.7469 mL 3.4938 mL 8.7345 mL
15 mM 0.2329 mL 1.1646 mL 2.3292 mL 5.8230 mL
20 mM 0.1747 mL 0.8735 mL 1.7469 mL 4.3673 mL
25 mM 0.1398 mL 0.6988 mL 1.3975 mL 3.4938 mL
30 mM 0.1165 mL 0.5823 mL 1.1646 mL 2.9115 mL
40 mM 0.0873 mL 0.4367 mL 0.8735 mL 2.1836 mL
50 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.7469 mL
60 mM 0.0582 mL 0.2912 mL 0.5823 mL 1.4558 mL
80 mM 0.0437 mL 0.2184 mL 0.4367 mL 1.0918 mL
100 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.8735 mL
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Azvudine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azvudine1011529-10-4RO-0622 FNCRO0622RO 0622Reverse TranscriptaseHIVHBVHCVHuman immunodeficiency virusHepatitis B virusHepatitis C virusNRTIresistantmutationanalogueInhibitorinhibitorinhibit

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