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BCAT-IN-2 

Cat. No.: HY-141669
Handling Instructions

BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema.

For research use only. We do not sell to patients.

BCAT-IN-2 Chemical Structure

BCAT-IN-2 Chemical Structure

CAS No. : 1800024-45-6

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Description

BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema[1].

IC50 & Target

pIC50: 7.3 (BCATm), 6.6 (BCATc)[1]

In Vitro

BCAT-IN-2 (compound 61) inhibits BCATm in differentiated primary human adipocyte, with pIC50 of 6.5[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BCAT-IN-2 (compound 61) (10-100 mg/kg; p.o.) increases the level of leucine from 473 μM to 1.2 mM at the dose of 100 mg/kg in mice[1].
BCAT-IN-2 (5 mg/kg for p.o. and 1 mg/kg for i.v.) exhibits a high bioavailability (F=100%), long half-life (t1/2=9.2 h) and low clearance (Cl=0.3 mL/min/kg) in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.78

Formula

C₁₇H₁₄ClF₂N₅O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BCAT-IN-2
Cat. No.:
HY-141669
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