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BCATc Inhibitor 2 

Cat. No.: HY-116044
Handling Instructions

BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively.

For research use only. We do not sell to patients.

BCATc Inhibitor 2 Chemical Structure

BCATc Inhibitor 2 Chemical Structure

CAS No. : 406191-34-2

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Description

BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively[1].

IC50 & Target

IC50: 0.2 μM (rBCATc), 0.8 μM (hBCATc), 3.0 μM (rBCATm)[1].

In Vitro

BCATc Inhibitor 2 decreases calcium influx in neuronal cultures with an IC50=4.8±1.2 μM[1].

In Vivo

BCATc Inhibitor 2 also blocks calcium influx into neuronal cells following inhibition of glutamate uptake, and demonstrates neuroprotective efficacy in vivo[1].
Following a 30 mg/kg subcutaneous injection to Lewis rats, BCATc Inhibitor 2 reaches a peak plasma concentration (Cmax) of 8.28 μg/mL at 0.5 h (tmax). The mean plasma exposure (AUC) value is 19.9 μg h/mL, and the mean terminal half-life ranged from 12 to 15 h, indicating favorable PK parameters of BCATc Inhibitor 2[1].

Molecular Weight

418.77

Formula

C₁₆H₁₀ClF₃N₂O₄S

CAS No.

406191-34-2

SMILES

ClC1=CC=C2C(C=C(O2)C(NNS(C3=C(C=CC=C3)C(F)(F)F)(=O)=O)=O)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BCATc Inhibitor 2BCATc Inhibitor2BCATc Inhibitor-2OthersBCATneurodegenerativediseasecytosolicrBCATchumanhBCATcmitochondrialrBCATmInhibitorinhibitorinhibit

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BCATc Inhibitor 2
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HY-116044
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