2. Anti-infection Epigenetics
  3. HIV hnRNP
  4. BMMP

BMMP is an anti-HIV-1 agent and hnRNP M modulator. BMMP modulates hnRNP M function to suppress CD44 mRNA expression. BMMP induces abnormal uncoating of the HIV viral core at the post-entry step. BMMP suppresses migration of TGF-β-stimulated lung carcinoma cells. BMMP suppresses HIV-1 reverse transcription and replication without inhibiting virion release. BMMP exerts anti-HIV-1 activity via a mechanism distinct from CA protein-binding heterocyclic compounds. BMMP can be used for the research of human immunodeficiency virus infection and non-small cell lung cancer.

For research use only. We do not sell to patients.

BMMP

BMMP Chemical Structure

CAS No. : 748785-70-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

BMMP Related Antibodies

Top Publications Citing Use of Products

View All HIV Isoform Specific Products:

View All Isoforms
HIV HIV-1 HIV-2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMMP is an anti-HIV-1 agent and hnRNP M modulator. BMMP modulates hnRNP M function to suppress CD44 mRNA expression. BMMP induces abnormal uncoating of the HIV viral core at the post-entry step. BMMP suppresses migration of TGF-β-stimulated lung carcinoma cells. BMMP suppresses HIV-1 reverse transcription and replication without inhibiting virion release. BMMP exerts anti-HIV-1 activity via a mechanism distinct from CA protein-binding heterocyclic compounds. BMMP can be used for the research of human immunodeficiency virus infection and non-small cell lung cancer[1][2].

In Vitro

BMMP (20 μM; 2 d) does not reduce the viability of 293T or M8166 cells[1].
BMMP (20 μM; 3 d) inhibits full-cycle HIV-1 replication across 293T and M8166 cells to 30% of control levels[1].
BMMP (20 μM) does not affect the release of HIV-1 virions from 293T cells[1].
BMMP (20 μM; 1 d) does not significantly alter the infectivity of HIV-1 virions produced by 293T cells[1].
BMMP (20 μM; 1 d) potently inhibits early-phase HIV-1 infectivity in M8166 cells to less than 10% of control levels[1].
BMMP (20 μM; 2 d) does not affect HIV-1 reverse transcription but suppresses nuclear localization and integration of viral DNA in 293T cells, reducing 2-LTR DNA to 60% and Alu-LTR DNA to 46% of control levels[1].
BMMP (20 μM; 1 d) destabilizes HIV-1 CA protein in infected HeLa cells[1].
BMMP (20 μM; 1 d) does not change the nuclear localization of hnRNP M but reduces HIV-1 CA protein levels in infected HeLa cells[1].
BMMP (20 μM; 1 d) inhibits early-phase HIV-1 infectivity in both control and hnRNP M-knockdown HeLa cells, indicating hnRNP M is not involved in BMMP's anti-HIV activity[1].
BMMP (0.1-100 μM; 2 d) at 0.1-50 μM does not reduce A549 cell viability, while 100 μM BMMP shows mild toxicity[1].
BMMP (0.1-100 μM; 24 h total incubation with TGF-β stimulation) inhibits TGF-β-induced migration of A549 cells in a concentration-dependent manner, with near-complete inhibition at 20 μM[1].
BMMP (20 μM; 1 h, 3 h, 6 h, or 1 d incubation with TGF-β stimulation) slightly reduces vimentin mRNA levels but does not inhibit TGF-β-induced EMT marker changes in A549 cells[1].
BMMP (20 μM; 1 d incubation with TGF-β stimulation) reduces TGF-β-induced increases in CD44s, CD44v8, and CD44v10 mRNA levels in A549 cells[1].
BMMP (20 μM; 1 d incubation with TGF-β stimulation) reduces TGF-β-induced CD44 mRNA expression in A549 cells via hnRNP M, as the effect is abolished in hnRNP M-knockdown cells[1].
BMMP (20 μM; up to 100 hours) inhibits replication of HIV-1 NL4-3 strain in human T-lymphoblastoid M8166 cells[2].
BMMP does not directly interact with HIV-1 Pr55Gag or CA protein in a cell-free surface plasmon resonance assay[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMMP Related Antibodies

Cell Viability Assay[1]

Cell Line: human kidney cell line 293T, human T-lymphoblastoid cell line M8166
Concentration: 20 μM
Incubation Time: 2 d
Result: Showed no significant toxicity to 293T or M8166 cells.
Maintained relative cell viability at ~100% compared to untreated controls.

Western Blot Analysis[1]

Cell Line: HeLa cells infected with HIV-1
Concentration: 20 μM
Incubation Time: 1 d
Result: Destabilized the HIV-1 CA (p24) protein, reducing its detectable levels compared to untreated controls.

Immunofluorescence[1]

Cell Line: HeLa cells infected with HIV-1
Concentration: 20 μM
Incubation Time: 1 d
Result: Did not alter the nuclear localization of hnRNP M.
Reduced detectable p24 (CA) protein levels.

Cell Viability Assay[1]

Cell Line: human lung carcinoma cell line A549
Concentration: 0.1 μM; 0.5 μM; 1 μM; 5 μM; 20 μM; 50 μM; 100 μM
Incubation Time: 2 d
Result: At 0.1-50 μM did not significantly reduce A549 cell viability (relative viability ~90-105% of control).
At 100 μM caused a slight reduction to ~85% of control.

Cell Migration Assay [1]

Cell Line: TGF-β-stimulated human lung carcinoma cell line A549
Concentration: 0.1 μM; 0.5 μM; 1 μM; 5 μM; 20 μM; 50 μM; 100 μM
Incubation Time: 24 h total incubation with TGF-β stimulation
Result: Inhibited TGF-β-induced A549 cell migration in a concentration-dependent manner.
Reduced migration by ~50% at 0.5 μM.
Nearly completely inhibited migration at 20 μM.
Maintained significant inhibitory activity at 100 μM.

RT-PCR[1]

Cell Line: TGF-β-stimulated human lung carcinoma cell line A549
Concentration: 20 μM
Incubation Time: 1 h, 3 h, 6 h, or 1 d incubation with TGF-β stimulation
Result: Did not alter E-cadherin mRNA levels.
Slightly reduced vimentin mRNA levels at 1 d post-TGF-β stimulation.
Did not significantly reduce N-cadherin, snail, or fibronectin mRNA levels after 1 d of TGF-β stimulation.

RT-PCR[1]

Cell Line: TGF-β-stimulated human lung carcinoma cell line A549
Concentration: 20 μM
Incubation Time: 1 d incubation with TGF-β stimulation
Result: Reduced TGF-β-induced increases in CD44s, CD44v8, and CD44v10 mRNA levels in A549 cells.

RT-PCR[1]

Cell Line: TGF-β-stimulated human lung carcinoma cell line A549 (hnRNP M-knockdown)
Concentration: 20 μM
Incubation Time: 1 d incubation with TGF-β stimulation
Result: Did not reduce TGF-β-induced increases in CD44s, CD44v8, or CD44v10 mRNA levels in hnRNP M-knockdown A549 cells.
Molecular Weight

273.38

Formula

C13H11N3S2
CAS No.
SMILES

CC1=NC(SCC2=NC3=C(S2)C=CC=C3)=NC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BMMP Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMMP748785-70-8HIVhnRNPHuman immunodeficiency virusHeterogeneous Ribonucleoproteinlung carcinoma cellshnRNP MM8166 cells293T cellsHIV viral coreTGF-βHeLa cellsA549 cellsCD44 mRNAHIV-1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BMMP
Cat. No.:
HY-182514
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.