(S)-Bleximenib oxalate
Based on 1 Customer Validation
(S)-Bleximenib (oxalate) is a S-Enantiomer of Bleximenib oxalate (HY-148669A). Bleximenib (JNJ-75276617) oxalate is an orally active and selective menin-KMT2A inhibitor, with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib oxalate can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib oxalate can be used in the research of tumors such as leukemia.
For research use only. We do not sell to patients.
- Purity: 98.37%
- Formula: C34H52FN7O7
- Molecular Weight:689.82
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-L016
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Anti-Blood Cancer Compound Library
HY-L079
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HY-L149
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
HY-L196
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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Methylation Compound Library
HY-L203
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High-Throughput Bioactive Compound Library
HY-L205
All Histone Methyltransferase Isoforms
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 689.82
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Formula C34H52FN7O7
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Color Off-white to light yellow
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SMILES
COCCN(C)CCC[C@H](N1CC2(C1)CN(C3=NC=NN=C3OC4=C(C=C(C=C4)F)C(N(CC)C(C)C)=O)CC2)C(C)C.O=C(O)C(O)=O
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Synonyms
(S)-JNJ-75276617 oxalate; (S)-Menin-MLL inhibitor 24 oxalate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (144.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4497 mL | 7.2483 mL | 14.4965 mL | 36.2413 mL |
| 5 mM | 0.2899 mL | 1.4497 mL | 2.8993 mL | 7.2483 mL | |
| 10 mM | 0.1450 mL | 0.7248 mL | 1.4497 mL | 3.6241 mL | |
| 15 mM | 0.0966 mL | 0.4832 mL | 0.9664 mL | 2.4161 mL | |
| 20 mM | 0.0725 mL | 0.3624 mL | 0.7248 mL | 1.8121 mL | |
| 25 mM | 0.0580 mL | 0.2899 mL | 0.5799 mL | 1.4497 mL | |
| 30 mM | 0.0483 mL | 0.2416 mL | 0.4832 mL | 1.2080 mL | |
| 40 mM | 0.0362 mL | 0.1812 mL | 0.3624 mL | 0.9060 mL | |
| 50 mM | 0.0290 mL | 0.1450 mL | 0.2899 mL | 0.7248 mL | |
| 60 mM | 0.0242 mL | 0.1208 mL | 0.2416 mL | 0.6040 mL | |
| 80 mM | 0.0181 mL | 0.0906 mL | 0.1812 mL | 0.4530 mL | |
| 100 mM | 0.0145 mL | 0.0725 mL | 0.1450 mL | 0.3624 mL |
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