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Crizotinib hydrochloride

(Synonyms: PF-02341066 hydrochloride)
89 Cited Publications
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Based on 89 publication(s) in Google Scholar

Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition.

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  • Pureté: 99.72%
  • CAS No.: 1415560-69-8
  • Formule: C21H23Cl3FN5O
  • Masse moléculaire:486.80
  • Stockage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Crizotinib hydrochloride Chemical Structure
    Crizotinib hydrochloride Chemical Structure
  • Experimental Validation Results for Crizotinib hydrochloride
  • Experimental Validation Results for Crizotinib hydrochloride
  • Experimental Validation Results for Crizotinib hydrochloride
  • Experimental Validation Results for Crizotinib hydrochloride
  • Experimental Validation Results for Crizotinib hydrochloride
  • Experimental Validation Results for Crizotinib hydrochloride
  • Experimental Validation Results for Crizotinib hydrochloride
  • Experimental Validation Results for Crizotinib hydrochloride
  • Experimental Validation Results for Crizotinib hydrochloride
CAS No.: 1415560-69-8
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  • Crizotinib hydrochloride Chemical Structure
    Crizotinib hydrochloride Chemical Structure
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    Crizotinib hydrochloride purchased from MedChemExpress. Usage Cited in: Evid Based Complement Alternat Med. 2019 Nov 7:2019:4253846. [Abstract]

    Customer Validation
     Western blot analysis of cleaved caspase 3, Bax, and Bcl-2 expression after serum-free culture for 72 h with or without Crizotinib.

  • 1/16

    Crizotinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2018 Aug 29;11(1):109. [Abstract]

    Customer Validation
     Resistant cells are treated with 200 nM Afatinib alone or in combination with 1 μM Crizotinib for 48 h.

  • 1/16

    Crizotinib hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2018 Mar;8(3):354-369. [Abstract]

    Customer Validation
     At 50mg/kg, Crizotinib inhibits MET phosphorylation and downstream signaling pathway activation.

  • 1/16

    Crizotinib hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2018 May 28:422:19-28. [Abstract]

    Customer Validation
     CD74-ROS1 or CD74-ROS1 G2032R mutation cells are treated with Crizotinib for 24 h, the expression of ROS1 or p-ROS1 is determined by western blot.

  • 1/16

    Crizotinib hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2017 Aug;11(8):996-1006. [Abstract]

    Customer Validation
     Dose-response and time course comparison of ALK inhibition by Crizotinib or Ceritinib.

  • 1/16

    Crizotinib hydrochloride purchased from MedChemExpress. Usage Cited in: Dis Model Mech. 2016 Sep 1;9(9):941-52. [Abstract]

    Customer Validation
     CLB-BAR, CLB-GE neuroblastoma cells are treated for 6 h with either Crizotinib or PF-04643922. Cells are harvested and pre-cleared cell lysates are analyzed on SDS PAGE followed by western blotting for ALK, phospho-ALK-Y1278, phospho-ERK5, pan-ERK5 phospho-ERK1/2 and pan-ERK. Actin is employed as a loading control. Protein band intensities are quantified by Image Studio Lite 3.1 and normalized to untreated samples.

  • 1/16

    Crizotinib hydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 May 17;7(20):29011-22. [Abstract]

    Customer Validation
     A, B. CLB-BAR (ALK-Δ4-11) and CLB-GE (ALK-F1174V), both ALK addicted cell lines, are treated with increasing doses of Brigatinib for 6 hours. Crizotinib (250 nM) is employed as a positive control. Cells lysates are resolved on SDS/PAGE followed by immunoblotting for pALK (Y1604) and additional downstream targets as indicated.

  • 1/16

    Crizotinib hydrochloride purchased from MedChemExpress. Usage Cited in: Sci Signal. 2014 Oct 28;7(349):ra102. [Abstract]

    Customer Validation
     Activation of ERK5 in neuroblastoma cell lines expressing activated ALK. (A to C) Immunoblotting for the indicated proteins in neuroblastoma cells CLB-BAR (A), CLB-GE (B), and IMR32 (C) cultured on six-well plates in complete growth medium and treated with inhibitors as indicated for 6 hours alone (A and B) or before (C) stimulation with mAb46 for 30 min.

  • 1/16

    Crizotinib hydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2014 May 15;5(9):2688-702. [Abstract]

    Customer Validation
     The Ret expression level is investigated by Western blot in MYCN/KI AlkR1279Q and MYCN/KI AlkF1178L treated tumors and controls using the anti-Ret antibody EPR2871. Actin is used as a standard for quantification.

  • Crizotinib hydrochloride