Antimalarial agent 50
Antimalarial agent 50 is an antiplasmodial compound. Antimalarial agent 50 has an effect against Plasmodium berghei induced malaria infection in mice model. Antimalarial agent 50 can regulate oxidative stress and significantly reduce the levels of inflammatory factors. Antimalarial agent 50 can be used for the research of the malaria.
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- CAS No.: 2384242-67-3
- Formule: C24H18N4OS
- Masse moléculaire:410.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:P. berghei NK 65 strain injected male Balb/c mice model (6-8 weeks)[1].
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Dosage:200-800 μg/kg, Positive control group Chloroquine (HY-17589A)
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Administration:Intraperitoneal injection (i.p.)
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Result:Showed the best anti parasitemia effect at 800 µg/kg with the inhibition rate of 83.6 %.
Restored RBCs similar to the vehicle control group.
Improved the condition of the ruffled fur and anxiety.
Significantly reversed RBCs, Hb, PCV, MCV, MCH, MCHC and platelets of infected mice.
Significantly reduced the concentration of AST, ALP, ALT and bilirubin, creatinine, uric acid and improved the pathological structure of the liver and spleen.
Improved the concentration of GSH, GST and CAT and reduced the concentration of NO and MDA.
Restored blood sugar levels in the infected mice.
Reduced the level of inflammatory factors NF-κB, IL-6, IFN-γ and decreased the level of the TNF-α, iNOS, IL-1β
Chemical Information
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CAS No. 2384242-67-3
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Masse moléculaire 410.49
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Formule C24H18N4OS
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SMILES
O=C(N1N=C(C2=CC=CC=C2)C=C1C3=CC=CC=C3)CSC4=NC5=CC=CC=C5N4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 50 Related Classifications
HY-174325 Related Classifications
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