(E/Z)-Oleamide
Based on 1 Customer Validation
(E/Z)-Oleamide (Octadec-9-enamide) is a PPARα ligand in hippocampal nuclei. (E/Z)-Oleamide can be isolated from plant Galium aparine L. (GA). (E/Z)-Oleamide controls hippocampal plasticity via transcriptional activation of CREB, and regulates feeding and sexual behavior in rats.
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- Pureté: 99.97%
- CAS No.: 3322-62-1
- Formule: C18H35NO
- Masse moléculaire:281.48
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Stockage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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mouse PPARα |
Chemical Information
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CAS No. 3322-62-1
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Appearance Solid
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Masse moléculaire 281.48
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Formule C18H35NO
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SMILES
O=C(CCCCCCC/C=C/CCCCCCCC)N
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Synonyms
Octadec-9-enamide
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvant et solubilité
DMSO : 50 mg/mL (177.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
Références
[1]. Roy A, et al. Identification and characterization of PPARα ligands in the hippocampus. Nat Chem Biol. 2016 Dec;12(12):1075-1083. [Content Brief]
[2]. Sahin B, et al. Galium aparine L. protects against acetaminophen-induced hepatotoxicity in rats. Chem Biol Interact. 2022 Oct 1;366:110119. [Content Brief]
[3]. Martínez-González D, et al. Oleamide and anandamide effects on food intake and sexual behavior of rats. Neurosci Lett. 2004 Jun 24;364(1):1-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5527 mL | 17.7633 mL | 35.5265 mL | 88.8163 mL |
| 5 mM | 0.7105 mL | 3.5527 mL | 7.1053 mL | 17.7633 mL | |
| 10 mM | 0.3553 mL | 1.7763 mL | 3.5527 mL | 8.8816 mL | |
| 15 mM | 0.2368 mL | 1.1842 mL | 2.3684 mL | 5.9211 mL | |
| 20 mM | 0.1776 mL | 0.8882 mL | 1.7763 mL | 4.4408 mL | |
| 25 mM | 0.1421 mL | 0.7105 mL | 1.4211 mL | 3.5527 mL | |
| 30 mM | 0.1184 mL | 0.5921 mL | 1.1842 mL | 2.9605 mL | |
| 40 mM | 0.0888 mL | 0.4441 mL | 0.8882 mL | 2.2204 mL | |
| 50 mM | 0.0711 mL | 0.3553 mL | 0.7105 mL | 1.7763 mL | |
| 60 mM | 0.0592 mL | 0.2961 mL | 0.5921 mL | 1.4803 mL | |
| 80 mM | 0.0444 mL | 0.2220 mL | 0.4441 mL | 1.1102 mL | |
| 100 mM | 0.0355 mL | 0.1776 mL | 0.3553 mL | 0.8882 mL |
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