HPK1-IN-35
HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC50 value of 3.5 nM. HPK1-IN-35 decreases the expression of p-SLP76 and promotes IL-2 secretion.
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- CAS No.: 2935903-77-6
- Formule: C30H32N8O3S
- Masse moléculaire:584.69
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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HPK1 3.5 nM (IC50) |
HPK1-IN-35 (compound 31) (0.1, 0.3, 1, 3 µM; 1 h) decreases the expression of p-SLP76 stimulated by anti-CD3 antibody (1 µg/mL) in a dose-dependent manner[1].
HPK1-IN-35 (0-10 µM; 24 h) promotes IL-2 secretion in Jurkat cells in a dose-dependent manner with EC50 values of 1.19 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells
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Concentration:0.1, 0.3, 1, 3 µM
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Incubation Time:1 h
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Result:Dose-dependently suppressed the phosphorylation of SLP76 stimulated by anti-CD3 antibody in Jurkat cells with IC50 values of 1.04 µM.
Chemical Information
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CAS No. 2935903-77-6
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Masse moléculaire 584.69
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Formule C30H32N8O3S
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SMILES
COC1=C(C=C2CN(CCC2=C1)C)NC3=NC4=C(C(NC5=CC=CC=C5S(=O)(N(C)C)=O)=N3)C(C6=CC=CN=C6)=CN4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HPK1-IN-35 Related Classifications
HY-149232 Related Classifications
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