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Cat. No.: HY-173601

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JAK3-IN-17

JAK3-IN-17 (Compound X15) is an orally active JAK3 inhibitor (IC₅₀: 14.56 nM). JAK3-IN-17 inhibits the production of IL-2 and IL-6 in a DNCB-induced mouse atopic dermatitis model and exhibits anti-inflammatory activity.

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Formule: C₂₁H₁₅FN₄O
Masse moléculaire:358.37

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

JAK3-IN-17 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

JAK3

14.56 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform JAK :

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	Plasma Concentration	AUC	MRT	Clearance (CL)	Bioavailability
Rat^[1]	2 mg/kg	i.v.	2.68 h	0.75 h	53.13 ng/mL	0.1042 μg·h/mL	1.66 h	19.56 L/h/kg	27.38 %
Rat^[1]	20 mg/kg	p.o.	20.33 h	0.5 h	29.7 ng/mL	0.9504 μg·h/mL	4.42 h	123.87 L/h/kg	/

Chemical Information

Masse moléculaire 358.37
Formule C₂₁H₁₅FN₄O
SMILES

O=C(C=C)NC1=CC=CC(C2=CN=C3C=CC(C4=C(F)N=CC=C4)=CN32)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ren W, et al. Discovery of novel JAK3 inhibitors for the treatment of atopic dermatitis. Bioorg Med Chem Lett. 2025 Aug 1;123:130219. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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JAK3-IN-17

Voir tous les produits spécifiques à Isoform JAK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

JAK3-IN-17 Related Classifications

HY-173601 Related Classifications