KRASG12C IN-15
KRASG12C IN-15 (Compound 21) is the orally active inhibitor for KRASG12C, and inhibits SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. KRASG12C IN-15 inhibits the phosphorylation of ERK with IC50 of 0.051 μM. KRASG12C IN-15 inhibits the cell viability of KRASG12C mutated MIA PaCa-2 with IC50 of 0.023 μM. KRASG12C IN-15 exhibits antitumor effect in MIA PaCa-2 xenograft mouse models.
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- CAS No.: 2768868-14-8
- Formule: C31H32FN3O2
- Masse moléculaire:497.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Chemical Information
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CAS No. 2768868-14-8
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Masse moléculaire 497.60
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Formule C31H32FN3O2
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SMILES
FC1=C(N2CC3(CN(C(C=C)=O)C3)CC2)N=C([C@H](C4)C(C)(C)[C@H]4C5)C5=C1C6=CC(O)=CC7=C6C=CC=C7
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRASG12C IN-15 Related Classifications
HY-173047 Related Classifications
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