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Cat. No.: HY-150060

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PDE4-IN-11

PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 (PDE4). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research.

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CAS No.: 524734-30-3
Formule: C₂₁H₁₉FN₂O₂
Masse moléculaire:350.39

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PDE4-IN-11 Chemical Structure

CAS No.: 524734-30-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

PDE4

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	EC₅₀	126 nM Compound: 53	Anti-inflammatory activity against human PBMCs assessed as reduction in LPS-induced TNF-alpha release by ELISA analysis Anti-inflammatory activity against human PBMCs assessed as reduction in LPS-induced TNF-alpha release by ELISA analysis	[PMID: 33569941]

In Vitro

PDE4-IN-11 (example 12) exerts function in the monocrotaline reversal model of pulmonary hypertension^[2].
PDE4-IN-11 (compound A1) displays antiinflammatory, anti-airways hyperreactivity and bronch odilator properties. PDE4-IN-11 also possesses immunosuppressive and TNFα secretion inhibitory activities^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 524734-30-3
Masse moléculaire 350.39
Formule C₂₁H₁₉FN₂O₂
SMILES

O=C(C1CCC(CC1)C2=CC3=C(N=CC=C3)C(C4=CC=CC(F)=C4)=N2)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Denholm A, et al. Preparation of naphthyridines as phosphodiesterase isoenzyme 4 (PDE4) inhibitors: World Intellectual Property Organization, WO2003039544[P]. 2003-05-15.

[2]. McCarthy C, et al. Use of naphthyridine derivatives as medicaments for the treatment of pulmonary hypertension: World Intellectual Property Organization, WO2007088019[P]. 2007-08-09.

[3]. Press NJ, et al. Organic compounds for treating pulmonary hypertension: World Intellectual Property Organization, WO2009013286. 2009-01-29.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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PDE4-IN-11

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PDE4-IN-11 Related Classifications

HY-150060 Related Classifications