PLK4-IN-1
Based on 1 Customer Validation
PLK4-IN-1 is a spiro cyclopropyl indolinone compound and PLK4 inhibitor with inhibitory activity against Aurora A and Aurora B kinases .PLK4-IN-1 can be used for the research of cancer .
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.84%
- CAS No.: 1247001-12-2
- Formule: C18H14IN3O2
- Masse moléculaire:431.23
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
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Kinase Inhibitor Library
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
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Heterocyclic Compound Library
HY-L138
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Serine/Threonine Kinase Inhibitor Library
HY-L164
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Voir tous les produits spécifiques à Isoform Aurora Kinase
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Activité biologique
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Aurora A |
Aurora B |
PLK4-IN-1 (compound A6) potently inhibits purified PLK4 kinase with an IC50 ≤ 0.1 μM. It inhibits purified Aurora A kinase, with an inhibition rate of less than 50% at an administration concentration of 1 μM. It also inhibits purified Aurora B kinase, with an IC50 greater than 0.1 μM and ≤ 1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1247001-12-2
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Appearance Solid
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Masse moléculaire 431.23
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Formule C18H14IN3O2
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Color White to off-white
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SMILES
O=C([C@@]12[C@H](C3=CC4=C(C=C3)C(I)=NN4)C1)NC5=C2C=C(OC)C=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 260 mg/mL (602.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3189 mL | 11.5947 mL | 23.1895 mL | 57.9737 mL |
| 5 mM | 0.4638 mL | 2.3189 mL | 4.6379 mL | 11.5947 mL | |
| 10 mM | 0.2319 mL | 1.1595 mL | 2.3189 mL | 5.7974 mL | |
| 15 mM | 0.1546 mL | 0.7730 mL | 1.5460 mL | 3.8649 mL | |
| 20 mM | 0.1159 mL | 0.5797 mL | 1.1595 mL | 2.8987 mL | |
| 25 mM | 0.0928 mL | 0.4638 mL | 0.9276 mL | 2.3189 mL | |
| 30 mM | 0.0773 mL | 0.3865 mL | 0.7730 mL | 1.9325 mL | |
| 40 mM | 0.0580 mL | 0.2899 mL | 0.5797 mL | 1.4493 mL | |
| 50 mM | 0.0464 mL | 0.2319 mL | 0.4638 mL | 1.1595 mL | |
| 60 mM | 0.0386 mL | 0.1932 mL | 0.3865 mL | 0.9662 mL | |
| 80 mM | 0.0290 mL | 0.1449 mL | 0.2899 mL | 0.7247 mL | |
| 100 mM | 0.0232 mL | 0.1159 mL | 0.2319 mL | 0.5797 mL |
PLK4-IN-1 Related Classifications
HY-134775 Related Classifications
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