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Cat. No.: HY-109072

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Riamilovir

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Riamilovir is an oral, broad-spectrum antiviral agent. Riamilovir can directly act on the virus's RNA-dependent RNA polymerase, thereby inhibiting viral replication, reducing viral load, and helping to alleviate the severity of the disease. Riamilovir can be used in research on acute respiratory viral infections caused by novel variants of SARS-CoV-2.

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CAS No.: 123606-06-4
Formule: C₅H₄N₆O₃S
Masse moléculaire:228.19

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Data Sheet (272 KB)

Riamilovir Chemical Structure

CAS No.: 123606-06-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- IC₅₀ & Target
- Cellular Effect
- In Vivo
- Essai clinique
Chemical Information
Publications (1)
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Activité biologique

Description

IC₅₀ & Target

RNA Polymerase

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	1513 μM Compound: Triazavirin	Cytotoxicity against human HEK293T cells measured after 72 hrs by MTT assay Cytotoxicity against human HEK293T cells measured after 72 hrs by MTT assay	[PMID: 33705902]
MDCK	CC₅₀	368 μM Compound: Triazavirin	Cytotoxicity against MDCK cells by MTT assay Cytotoxicity against MDCK cells by MTT assay	[PMID: 33705902]

In Vivo

Riamilovir (250 mg capsules, once daily; orally for 10 consecutive days) demonstrated broad-spectrum antiviral activity against influenza, tick-borne encephalitis, and SARS-CoV-2 in a randomized, double-blind, multicenter trial. It was able to reduce the viral load of SARS-CoV-2 in vivo without severe adverse reactions^[1].
Riamilovir (0.85 mg/kg; orally once daily for 7 consecutive days) produced a significant endothelial protective effect in male C57BL/6 mice with endothelial dysfunction induced by L-NAME. This substance reduced the levels of MMP-2 and MMP-9 in the aortic supernatant of mice by 20.4% and 19.5%, respectively, and downregulated the level of iNOS in the aorta by 57.2% and upregulated the level of eNOS by 40.0%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 123606-06-4
Masse moléculaire 228.19
Formule C₅H₄N₆O₃S
SMILES

O=C1N(N=C(SC)N2)C2=NN=C1[N+]([O-])=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Med Virol

Drug Repurposing: In Vitro Evaluation of Simeprevir as a Novel Antiviral Drug Against Severe Fever With Thrombocytopenia Syndrome Virus. [Abstract]

2025 Oct;97(10):e70655. PMID: 41117261

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sabitov AU, et al. Results of a randomized double-blind multicenter clinical trial of the efficacy and safety of the drug riamilovir for the prevention of COVID-19. Terapevticheskii Arkhiv, 2024, 96(3):280-285.

[2]. Haritonova O, et al. Evaluation of the Endothelioprotective Effect of Certain Antiviral Agents in Conditions of Experimental Endothelial Dysfunction. Crimea Journal of Experimental and Clinical Medicine, 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Riamilovir

1 Cited Publications

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- In Vivo
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Publications (1)
Pureté et documentation
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Riamilovir

Publications Citing Use of MedChemExpress (MCE) Riamilovir

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

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Publications (1)

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Riamilovir Related Classifications

HY-109072 Related Classifications