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Art. -Nr.: HY-109072A

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Riamilovir sodium

Riamilovir sodium is an oral, broad-spectrum antiviral agent. Riamilovir sodium can directly act on the virus's RNA-dependent RNA polymerase, thereby inhibiting viral replication, reducing viral load, and helping to alleviate the severity of the disease. Riamilovir sodium can be used in research on acute respiratory viral infections caused by novel variants of SARS-CoV-2.

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CAS. Nr.: 116061-59-7
Formel: C₅H₄N₆NaO₃S
Molecular Weight:251.18

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Riamilovir sodium Chemical Structure

CAS. Nr.: 116061-59-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

RNA Polymerase

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In Vivo

Riamilovir (250 mg capsules, once daily; orally for 10 consecutive days) sodium demonstrated broad-spectrum antiviral activity against influenza, tick-borne encephalitis, and SARS-CoV-2 in a randomized, double-blind, multicenter trial. It was able to reduce the viral load of SARS-CoV-2 in vivo without severe adverse reactions^[1].
Riamilovir (0.85 mg/kg; orally once daily for 7 consecutive days) sodium produced a significant endothelial protective effect in male C57BL/6 mice with endothelial dysfunction induced by L-NAME. This substance reduced the levels of MMP-2 and MMP-9 in the aortic supernatant of mice by 20.4% and 19.5%, respectively, and downregulated the level of iNOS in the aorta by 57.2% and upregulated the level of eNOS by 40.0%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 116061-59-7
Molecular Weight 251.18
Formel C₅H₄N₆NaO₃S
SMILES

O=C1N(N=C(SC)N2)C2=NN=C1[N+]([O-])=O.[Na]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Sabitov AU, et al. Results of a randomized double-blind multicenter clinical trial of the efficacy and safety of the drug riamilovir for the prevention of COVID-19. Terapevticheskii Arkhiv, 2024, 96(3):280-285.

[2]. Haritonova O, et al. Evaluation of the Endothelioprotective Effect of Certain Antiviral Agents in Conditions of Experimental Endothelial Dysfunction. Crimea Journal of Experimental and Clinical Medicine, 2025.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vivo
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Riamilovir sodium

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Riamilovir sodium Related Classifications

HY-109072A Related Classifications