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Cat. No.: HY-N20627

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Withametelin B

Withametelin B is a hexacyclic withanolide that can be isolated from Datura metel leaves. Withametelin B can bind to Bcl-2.

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CAS No.: 123523-09-1
Formule: C₂₈H₃₆O₅
Masse moléculaire:452.58

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Please store the product under the recommended conditions in the Certificate of Analysis.

Withametelin B Chemical Structure

CAS No.: 123523-09-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- In Vitro
Chemical Information
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Activité biologique

Description

Withametelin B is a hexacyclic withanolide that can be isolated from Datura metel leaves. Withametelin B can bind to Bcl-2^[1]^[2].

Voir tous les produits spécifiques à Isoform Bcl-2 Family :

In Vitro

Withametelin B binds to purified Bcl-2 (PDB ID 6O0K) with a binding affinity of -8.8 kcal/mol, interacting with key functional residues of the protein's BH1 domain^[1].
Withametelin B binds to Bcl-2 with a favorable binding free energy of -32.22 kJ/mol, confirming a strong stable interaction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 123523-09-1
Masse moléculaire 452.58
Formule C₂₈H₃₆O₅
SMILES

C[C@@]12[C@](CC[C@]2([H])[C@@]3([H])[C@@]4([H])C[C@@](OC3)(C(C(O4)=O)=C)C)([H])[C@@]5([H])[C@@](CC1)([H])[C@@]6(C([C@@H](C5)O)=CC=CC6=O)C
Structure Classification
- Others
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Alkhathami AG, et al. Phytochemicals Daturilinol and Withametelin B identified as novel Bcl2 inhibitors via virtual screening and molecular simulations. Sci Rep. 2025;15(1):33029. Published 2025 Sep 26. [Content Brief]

[2]. Mohini Gupta, et al. Additional Withanolides of Datura metel. J. Nat. Prod. 1991, 54, 2, 599-602.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Withametelin B

Voir tous les produits spécifiques à Isoform Bcl-2 Family

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Withametelin B Related Classifications

HY-N20627 Related Classifications