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Cat. No.: HY-176457

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ZS3-046

ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model.
(Pink: TAF1 ligand (HY-176467); Blue: Cereblon ligand (HY-41547); Black: linker (HY-176469)).

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CAS No.: 3087879-97-5
Formule: C₄₉H₅₇N₉O₇
Masse moléculaire:884.03

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

ZS3-046 Chemical Structure

CAS No.: 3087879-97-5

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Fluorescent Dye

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Activité biologique

Description

ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model^[1]. (Pink: TAF1 ligand (HY-176467); Blue: Cereblon ligand (HY-41547); Black: linker (HY-176469)).

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Chemical Information

CAS No. 3087879-97-5
Masse moléculaire 884.03
Formule C₄₉H₅₇N₉O₇
SMILES

O=C(N1C2CCC(NC2=O)=O)C3=C(NCC4CCN(CCCCCCCN5C6=C(C(C(C7=C8NC=C7)=CN(CCC=C)C8=O)=CC(C(N9CCOCC9)=O)=C6)N=C5)CC4)C=CC=C3C1=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen L, et al. PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo. Mol Cancer Ther. 2025 May 16:OF1-OF10. [Content Brief]

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ZS3-046

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

ZS3-046 Related Classifications

HY-176457 Related Classifications