2. Apoptosis Others
  3. Bcl-2 Family Drug Derivative
  4. Caylin-2

Caylin-2 is a Bcl-XL binder and analog of Nutlin-3 (HY-50696). Caylin-2 interacts with the hydrophobic groove of Bcl-XL, with binding diminished by steric collision from its trifluoromethyl groups. Caylin-2 can be used for cancer research.

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Caylin-2

Caylin-2 Chemical Structure

CAS No. : 1392830-09-9

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Based on 1 publication(s) in Google Scholar

Caylin-2 Related Antibodies

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Description

Caylin-2 is a Bcl-XL binder and analog of Nutlin-3 (HY-50696). Caylin-2 interacts with the hydrophobic groove of Bcl-XL, with binding diminished by steric collision from its trifluoromethyl groups. Caylin-2 can be used for cancer research[1].

IC50 & Target[1]

Bcl-xL

 

In Vitro

Caylin-2 binds to the conserved hydrophobic groove of purified Bcl-XL protein but induces substantially diminished chemical shift perturbations, indicating weaker binding than Nutlin-3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Caylin-2 Related Antibodies
Masse moléculaire

648.60

Formule

C32H30F6N4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CC(NCC1)=O)N2[C@@H](C3=CC=C(C=C3)C(F)(F)F)[C@@H](C4=CC=C(C=C4)C(F)(F)F)N=C2C5=C(C=C(C=C5)OC)OC(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pureté et documentation
Références
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Caylin-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Caylin-21392830-09-9Caylin2Caylin 2Bcl-2 FamilyDrug DerivativeDrug derivativeBcl-X? proteinBcl-XLhydrophobic grooveInhibitorinhibitorinhibit

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