Axinelline A
Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity.
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- CAS. Nr.: 1593741-99-1
- Formel: C12H15NO6
- Molecular Weight:269.25
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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COX-2 2.22 μM (IC50) |
COX-1 8.89 μM (IC50) |
Axinelline A (2-30 μM; 24 h) inhibits Lipopolysaccharide (LPS; HY-D1056)-induced expression of pro-inflammatory factors (NO, TNF-α, IL-6, IL-1β, and PGE2) in RAW264.7 cells[1].
Axinelline A (2-30 μM; 24 h) inhibits LPS-induced NF-κB signaling pathway in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:2, 10 and 30 μM
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Incubation Time:24 h
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Result:Diminished LPS-induced expression of nitric oxide synthase (iNOS) and COX-2 protein levels. The phosphorylation level of NF-κB increased after 30 min of LPS treatment, but pretreatment with test compound reduced the level of phosphorylation in a dose-dependent manner. The phosphorylation of IKK and IκBα was inhibited in a dose-dependent manner.
Chemical Information
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CAS. Nr. 1593741-99-1
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Molecular Weight 269.25
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Formel C12H15NO6
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SMILES
CCOC([C@H](CO)NC(C1=C(C(O)=CC=C1)O)=O)=O
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Structure Classification
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Initial Source
Streptomyces axinellae
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Axinelline A Related Classifications
HY-N11624 Related Classifications
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